By curating a current list of publications by HypOxystation users, HypOxygen is striving to provide a resource for researchers interested in investigating their cells under truly authentic, physiological culture conditions. Low oxygen, be it hypoxia as a pathological parameter or physioxia as the natural condition for cells, both in vivo and in vitro, is reliably created in the HypOxystation. We hope the science community will find these papers, which are searchable and linked to the original papers, to be useful in elucidating the importance of hypoxic cell culture in their own labs.

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Research Field Authors Title of Paper Citation/Journal Publication Date Country
of Origin
Link to Publication
Neurology van Kessel, et al. Gut bacterial tyrosine decarboxylases restrict levels of levodopa in the treatment of Parkinson’s disease Nat Commun. 2019; 10: 310. 2019 Netherlands Click for
Article
Cancer Jarman, et al. HER2 regulates HIF-2α and drives an increased hypoxic response in breast cancer Breast Cancer Res. 2019; 21: 10. 2019 United Kingdom Click for
Article
Pathology La Rosa, et al. Wood-Derived Dietary Fibers Promote Beneficial Human Gut Microbiota mSphere. 2019 Jan-Feb; 4(1): e00554-18. 2019 Norway Click for
Article
Pathology Theophilou, et al. Generation of Markerless Deletions in the Nosocomial Pathogen Clostridium difficileby Induction of DNA Double-Strand Breaks Appl Environ Microbiol. 2019 Feb 1; 85(3): e02055-18. 2019 United Kingdom Click for
Article
Microbiology Bjerke, et al. Exploring the Brine Microbiota of a Traditional Norwegian Fermented Fish Product (Rakfisk) from Six Different Producers during Two Consecutive Seasonal Productions Foods. 2019 Feb; 8(2): 72. 2019 Norway Click for
Article
Pathology Quigley, et al. Lactobacillus gasseriAPC 678 Reduces Shedding of the Pathogen Clostridium difficilein a Murine Model Front Microbiol. 2019; 10: 273. 2019 Ireland Click for
Article
Hypoxia General Merceron, et al. Hypoxia-inducible factor 2α is a negative regulator of osteoblastogenesis and bone mass accrual Bone Res. 2019; 7: 7. 2019 United States Click for
Article
Microbiology La Rosa, et al. The human gut Firmicute Roseburia intestinalisis a primary degrader of dietary β-mannans Nat Commun. 2019; 10: 905. 2019 Norway Click for
Article
Microbiology Cabal, et al. Bactericidal ZnO glass-filled thermoplastic polyurethane and polydimethyl siloxane composites to inhibit biofilm-associated infections Sci Rep. 2019; 9: 2762. 2019 Spain Click for
Article
Cancer Zhang, et al. Hypoxic BMSC-derived exosomal miRNAs promote metastasis of lung cancer cells via STAT3-induced EMT Mol Cancer. 2019; 18: 40. 2019 China Click for
Article
Cancer Lee, et al. Spatial-fluxomics provides a subcellular-compartmentalized view of reductive glutamine metabolism in cancer cells Nat Commun. 2019; 10: 1351. 2019 Israel Click for
Article
Microbiology Hallberg, et al. Structure and mechanism of a Hypr GGDEF enzyme that activates cGAMP signaling to control extracellular metal respiration eLife. 2019; 8: e43959. 2019 United States Click for
Article
Microbiology Bassan, et al. TePhe, a tellurium-containing phenylalanine mimic, allows monitoring of protein synthesis in vivo with mass cytometry Proc Natl Acad Sci U S A. 2019 Apr 23; 116(17): 8155–8160. 2019 Canada Click for
Article
Hypoxia General Pallett, et al. Anaerobiosis influences virulence properties of Pseudomonas aeruginosacystic fibrosis isolates and the interaction with Staphylococcus aureus Sci Rep. 2019; 9: 6748. 2019 United Kingdom Click for
Article
Microbiology Chen, et al. Increasing sulfate levels show a differential impact on synthetic communities comprising different methanogens and a sulfate reducer J R Soc Interface. 2019 May; 16(154): 20190129. 2019 United Kingdom Click for
Article
Cancer Cheng, et al. 2-Oxonanonoidal Antibiotic Actinolactomycin Inhibits Cancer Progression by Suppressing HIF-1α Cells. 2019 May; 8(5): 439. 2019 China Click for
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Cancer Wohlrab, et al. Ascorbate modulates the hypoxic pathway by increasing intracellular activity of the HIF hydroxylases in renal cell carcinoma cells Hypoxia (Auckl). 2019; 7: 17–31. 2019 United Kingdom Click for
Article
Pathology Branchu, et al. SGI-4 in Monophasic SalmonellaTyphimurium ST34 Is a Novel ICE That Enhances Resistance to Copper Front Microbiol. 2019; 10: 1118. 2019 United Kingdom Click for
Article
Pathology Davies, et al. Sodium Taurocholate Stimulates Campylobacter jejuniOuter Membrane Vesicle Production via Down-Regulation of the Maintenance of Lipid Asymmetry Pathway Front Cell Infect Microbiol. 2019; 9: 177. 2019 United Kingdom Click for
Article
Dental Coil, et al. Genomes from bacteria associated with the canine oral cavity: A test case for automated genome-based taxonomic assignment PLoS One. 2019; 14(6): e0214354. 2019 United States Click for
Article
Dental Lombardo, et al. A Topical Desiccant Agent in Association with Manual Debridement in the Initial Treatment of Peri-Implant Mucositis: A Clinical and Microbiological Pilot Study Antibiotics (Basel). 2019 Jun; 8(2): 82. 2019 Italy Click for
Article
Cancer Swadi, et al. CDK inhibitors reduce cell proliferation and reverse hypoxia-induced metastasis of neuroblastoma tumours in a chick embryo model Sci Rep. 2019; 9: 9136. 2019 United Kingdom Click for
Article
Cancer Hay, et al. Benzotriazine Di-Oxide Prodrugs for Exploiting Hypoxia and Low Extracellular pH in Tumors Molecules. 2019 Jul; 24(14): 2524. 2019 New Zealand Click for
Article
Pathology Pander, et al. The carbonic anhydrase of Clostridium autoethanogenumrepresents a new subclass of β-carbonic anhydrases Appl Microbiol Biotechnol. 2019; 103(17): 7275–7286. 2019 United Kingdom Click for
Article
Hypoxia General Soyal, et al. The Expression of CNS-Specific PPARGC1ATranscripts Is Regulated by Hypoxia and a Variable GT Repeat Polymorphism Mol Neurobiol. 2020; 57(2): 752–764. 2020 Austria Click for
Article
Microbiology Mörtelmaier, et al. Identification performance of MALDI-ToF-MS upon mono- and bi-microbial cultures is cell number and culture proportion dependent Anal Bioanal Chem. 2019; 411(26): 7027–7038. 2019 United Kingdom Click for
Article
Microbiology Braune, et al. An NADH-Dependent Reductase from Eubacterium ramulusCatalyzes the Stereospecific Heteroring Cleavage of Flavanones and Flavanonols Appl Environ Microbiol. 2019 Oct 1; 85(19): e01233-19. 2019 Germany Click for
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Microbiology Ahmed, et al. In vitroCharacterization of Gut Microbiota-Derived Bacterial Strains With Neuroprotective Properties Front Cell Neurosci. 2019; 13: 402. 2019 United Kingdom Click for
Article
Dental Belkacemi, et al. Passive Filtration, Rapid Scanning Electron Microscopy, and Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry for TreponemaCulture and Identification from the Oral Cavity J Clin Microbiol. 2019 Oct; 57(10): e00517-19. 2019 France Click for
Article
Pathology Le Maréchal, et al. Evaluation of the occurrence of sporulating and nonsporulating pathogenic bacteria in manure and in digestate of five agricultural biogas plants Microbiologyopen. 2019 Oct; 8(10): e872. 2019 France Click for
Article
Microbiology Bell, et al. Elucidation of a unique sialic acid metabolism pathway in mucus-foraging Ruminococcus gnavusunravels mechanisms of bacterial adaptation to the gut Nat Microbiol. Author manuscript; available in PMC 2020 Apr 21. 2019 United Kingdom Click for
Article
Pathology Shaw, et al. Clostridium difficileclade 3 (RT023) have a modified cell surface and contain a large transposable island with novel cargo Sci Rep. 2019; 9: 15330. 2019 United Kingdom Click for
Article
Pathology AlKalbani, et al. Isolation, identification, and potential probiotic characterization of isolated lactic acid bacteria and in vitro investigation of the cytotoxicity, antioxidant, and antidiabetic activities in fermented sausage Microb Cell Fact. 2019; 18: 188. 2020 United Arab Emirates Click for
Article
Pathology Chen, et al. Lysophosphatidic acid receptor LPA3prevents oxidative stress and cellular senescence in Hutchinson–Gilford progeria syndrome Aging Cell. 2020 Jan; 19(1): e13064. 2020 Taiwan Click for
Article
Pathology Tyc, et al. The ecological role of bacterial seed endophytes associated with wild cabbage in the United Kingdom Microbiologyopen. 2020 Jan; 9(1): e00954. 2020 Netherlands Click for
Article
Microbiology Liaw, et al. The Campylobacter jejuniType VI Secretion System Enhances the Oxidative Stress Response and Host Colonization Front Microbiol. 2019; 10: 2864. 2019 United Kingdom Click for
Article
Microbiology Senizza, et al. Effects of Linoleic Acid on Gut-Derived Bifidobacterium breveDSM 20213: A Transcriptomic Approach Microorganisms. 2019 Dec; 7(12): 710. 2019 Italy Click for
Article
Cancer Venkatesh, et al. Hypoxia increases mutational load of breast cancer cells through frameshift mutations Oncoimmunology. 2020; 9(1): 1750750. 2020 United Arab Emirates Click for
Article
Microbiology Labourel, et al. Structural and functional analyses of glycoside hydrolase 138 enzymes targeting chain A galacturonic acid in the complex pectin rhamnogalacturonan II J Biol Chem. 2019 May 10; 294(19): 7711–7721. 2019 United Kingdom Click for
Article
Pathology Chen, et al. Quantification of Human Oral and Fecal Streptococcus parasanguinisby Use of Quantitative Real-Time PCR Targeting the groELGene Front Microbiol. 2019; 10: 2910. 2019 China Click for
Article
Microbiology Oliveira, et al. Chemical Constituents and Antileishmanial and Antibacterial Activities of Essential Oils from Scheelea phalerata ACS Omega. 2020 Jan 28; 5(3): 1363–1370. 2020 Brazil Click for
Article
Microbiology Silvan, et al. Modulation of Antibacterial, Antioxidant, and Anti-Inflammatory Properties by Drying of Prunus domesticaL. Plum Juice Extracts Microorganisms. 2020 Jan; 8(1): 119. 2020 Spain Click for
Article
Cancer Casciati, et al. Human Medulloblastoma Cell Lines: Investigating on Cancer Stem Cell-Like Phenotype Cancers (Basel). 2020 Jan; 12(1): 226. 2020 Italy Click for
Article
Pathology Axelsson, et al. Growth Behavior of Listeria monocytogenesin a Traditional Norwegian Fermented Fish Product (Rakfisk), and Its Inhibition through Bacteriophage Addition Foods. 2020 Feb; 9(2): 119. 2020 Norway Click for
Article
Pathology Liang, et al. Development of a Lyophilization Process for CampylobacterBacteriophage Storage and Transport Microorganisms. 2020 Feb; 8(2): 282. 2020 United Kingdom Click for
Article
Microbiology Garcia-Gutierrez, et al. First evidence of production of the lantibiotic nisin P Sci Rep. 2020; 10: 3738. 2020 United Kingdom Click for
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Microbiology Ayyash, et al. Bioactive Properties of Novel Probiotic Lactococcus lactisFermented Camel Sausages: Cytotoxicity, Angiotensin Converting Enzyme Inhibition, Antioxidant Capacity, and Antidiabetic Activity Food Sci Anim Resour. 2020 Mar; 40(2): 155–171. 2020 United Arab Emirates Click for
Article
Microbiology Filandr, et al. The H2O2-dependent activity of a fungal lytic polysaccharide monooxygenase investigated with a turbidimetric assay Biotechnol Biofuels. 2020; 13: 37. 2020 Czech Republic Click for
Article
Microbiology Kmezik, et al. Multimodular fused acetyl–feruloyl esterases from soil and gut Bacteroidetes improve xylanase depolymerization of recalcitrant biomass Biotechnol Biofuels. 2020; 13: 60. 2020 Sweden Click for
Article
Cardiology Zhao, et al. The role of miR-711 in cardiac cells in response to oxidative stress and its biogenesis: a study on H9C2 cells Cell Mol Biol Lett. 2020; 25: 26. 2020 China Click for
Article
Dental Kõljalg, et al. Exploration of singular and synergistic effect of xylitol and erythritol on causative agents of dental caries Sci Rep. 2020; 10: 6297. 2020 Estonia Click for
Article
Pathology Phanchana, et al. Repurposing a platelet aggregation inhibitor ticagrelor as an antimicrobial against Clostridioides difficile Sci Rep. 2020; 10: 6497. 2020 Thailand Click for
Article
Microbiology Kovács, et al. Stress Response and Virulence Potential Modulating Effect of Peppermint Essential Oil inCampylobacter jejuni Biomed Res Int. 2019; 2019: 2971741. 2019 Hungary Click for
Article
Pathology Wei, et al. Prevalence, genotype and antimicrobial resistance of Clostridium difficileisolates from healthy pets in Eastern China BMC Infect Dis. 2019; 19: 46. 2019 China Click for
Article
Cancer Roig, et al. HIF-1α and HIF-2α Differently Regulate the Radiation Sensitivity of NSCLC Cells Cells. 2019 Jan; 8(1): 45. 2019 Netherlands Click for
Article
Dental Brewer, et al. Fusobacteriumspp. target human CEACAM1 via the trimeric autotransporter adhesin CbpF J Oral Microbiol. 2019; 11(1): 1565043. 2019 United Kingdom Click for
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Microbiology Lauté-Caly, et al. The flagellin of candidate live biotherapeutic Enterococcus gallinarumMRx0518 is a potent immunostimulant Sci Rep. 2019; 9: 801. 2019 United Kingdom Click for
Article
Cancer Kugeratski, et al. Hypoxic cancer-associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling Sci Signal. Author manuscript; available in PMC 2019 Oct 15. 2019 United Kingdom Click for
Article
Microbiology Chen, et al. Megasphaera elsdeniiLactate Degradation Pattern Shifts in Rumen Acidosis Models Front Microbiol. 2019; 10: 162. 2019 China Click for
Article
Microbiology Blandford, et al. Promoter orientation of the immunomodulatory Bacteroides fragiliscapsular polysaccharide A (PSA) is off in individuals with inflammatory bowel disease (IBD) Gut Microbes. 2019; 10(5): 569–577. 2019 United Kingdom Click for
Article
Dental Pacha-Olivenza, et al. Relevance of Topographic Parameters on the Adhesion and Proliferation of Human Gingival Fibroblasts and Oral Bacterial Strains Biomed Res Int. 2019; 2019: 8456342. 2019 Spain Click for
Article
Microbiology Wheeler, et al. Genomic correlates of extraintestinal infection are linked with changes in cell morphology in Campylobacter jejuni Microb Genom. 2019 Feb; 5(2): e000251. 2019 United Kingdom Click for
Article
Pathology Sharma, et al. Survival of Escherichia coliin Manure-Amended Soils Is Affected by Spatiotemporal, Agricultural, and Weather Factors in the Mid-Atlantic United States Appl Environ Microbiol. 2019 Mar 1; 85(5): e02392-18. 2019 United States Click for
Article
Cancer Buckley, et al. Characterisation of an Isogenic Model of Cisplatin Resistance in Oesophageal Adenocarcinoma Cells Pharmaceuticals (Basel). 2019 Mar; 12(1): 33. 2019 Ireland Click for
Article
Microbiology Atmadjaja, et al. CRISPR-Cas, a highly effective tool for genome editing in Clostridium saccharoperbutylacetonicumN1-4(HMT) FEMS Microbiol Lett. 2019 Mar; 366(6): fnz059. 2019 United Kingdom Click for
Article
Pathology Vishwanath, et al. Antimicrobial Resistance Profile and NimGene Detection among Bacteroides fragilisGroup Isolates in a University Hospital in South India J Glob Infect Dis. 2019 Apr-Jun; 11(2): 59–62. 2019 India Click for
Article
Dental Naginyte, et al. Enrichment of periodontal pathogens from the biofilms of healthy adults Sci Rep. 2019; 9: 5491. 2019 United Kingdom Click for
Article
Cancer Cowman, et al. Decrease of Nibrin expression in chronic hypoxia is associated with hypoxia-induced chemoresistance in some brain tumour cells BMC Cancer. 2019; 19: 300. 2019 United Kingdom Click for
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Pathology Esvaran and Conway Lactobacillus fermentumPC1 has the Capacity to Attenuate Joint Inflammation in Collagen-Induced Arthritis in DBA/1 Mice Nutrients. 2019 Apr; 11(4): 785. 2019 Australia Click for
Article
Microbiology Rawlings, et al. Protective role of the deSUMOylating enzyme SENP3 in myocardial ischemia-reperfusion injury PLoS One. 2019; 14(4): e0213331. 2019 United Kingdom Click for
Article
Cardiology Zhang, et al. Aldehyde Dehydrogenase 2 Protects Against Post-Cardiac Arrest Myocardial Dysfunction Through a Novel Mechanism of Suppressing Mitochondrial Reactive Oxygen Species Production Front Pharmacol. 2020; 11: 373. 2020 China Click for
Article
Microbiology Loeffler, et al. Influence of Protein Type on the Antimicrobial Activity of LAE Alone or in Combination with Methylparaben Foods. 2020 Mar; 9(3): 270. 2020 Germany Click for
Article
Pathology Abouelhadid, et al. Quantitative Analyses Reveal Novel Roles for N-Glycosylation in a Major Enteric Bacterial Pathogen mBio. 2019 Mar-Apr; 10(2): e00297-19. 2019 United Kingdom Click for
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Pathology Anonye, et al. Probing Clostridium difficile Infection in Complex Human Gut Cellular Models Front Microbiol. 2019; 10: 879. 2019 United Kingdom Click for
Article
Microbiology Kim, et al. Hypoxia-Induced Epithelial-To-Mesenchymal Transition Mediates Fibroblast Abnormalities via EKR Activation in Cutaneous Wound Healing Int J Mol Sci. 2019 May; 20(10): 2546. 2019 Korea Click for
Article
Pathology Xiao, et al. Modeling the Reduction of Salmonella spp. on Chicken Breasts and Wingettes during Scalding for QMRA of the Poultry Supply Chain in China Microorganisms. 2019 Jun; 7(6): 165. 2019 China Click for
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Dental Saquib, et al. Evaluation and Comparison of Antibacterial Efficacy of Herbal Extracts in Combination with Antibiotics on Periodontal pathobionts: An in vitro Microbiological Study Antibiotics (Basel). 2019 Sep; 8(3): 89. 2019 Saudi Arabia Click for
Article
Microbiology Zhai, et al. Strain-Specific Anti-inflammatory Properties of Two Akkermansia muciniphila Strains on Chronic Colitis in Mice Front Cell Infect Microbiol. 2019; 9: 239. 2019 China Click for
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Pathology Slater, et al. Clostridioides difficile LuxS mediates inter-bacterial interactions within biofilms Sci Rep. 2019; 9: 9903. 2019 United Kingdom Click for
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Cancer Boso, et al. HIF-1α/Wnt signaling-dependent control of gene transcription regulates neuronal differentiation of glioblastoma stem cells Theranostics. 2019; 9(17): 4860–4877. 2019 Italy Click for
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Microbiology Bellali, et al. Among Live and Dead Bacteria, the Optimization of Sample Collection and Processing Remains Essential in Recovering Gut Microbiota Components Front Microbiol. 2019; 10: 1606. 2019 France Click for
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Dental Cleaver, et al. Mixed aerobic-anaerobic incubation conditions induce proteolytic activity from in vitro salivary biofilms J Oral Microbiol. 2019; 11(1): 1643206. 2019 United Kingdom Click for
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Microbiology Chrdle, et al. Francisella tularensis Periprosthetic Joint Infections Diagnosed with Growth in Cultures J Clin Microbiol. 2019 Aug; 57(8): e00339-19. 2019 Czech Republic Click for
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Microbiology Barba, et al. Abdominal distension after eating lettuce: The role of intestinal gas evaluated in vitro and by abdominal CT imaging Neurogastroenterol Motil. 2019 Dec; 31(12): e13703. 2019 Spain Click for
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Pathology Simecka, et al. Primary care clinics can be a source of exposure to virulent Clostridium (now Clostridioides) difficile: An environmental screening study of hospitals and clinics in Dallas-Fort Worth region PLoS One. 2019; 14(8): e0220646. 2019 United States Click for
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Pathology Bradshaw, et al. Molecular features of lipoprotein CD0873: A potential vaccine against the human pathogen Clostridioides difficile J Biol Chem. 2019 Oct 25; 294(43): 15850–15861. 2019 United Kingdom Click for
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Microbiology Wei, et al. Adaptational changes in physiological and transcriptional responses of Bifidobacterium longum involved in acid stress resistance after successive batch cultures Microb Cell Fact. 2019; 18: 156. 2019 China Click for
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Microbiology Oka, et al. Phosphoinositide 3-Kinase P110δ-Signaling Is Critical for Microbiota-Activated IL-10 Production by B Cells that Regulate Intestinal Inflammation Cells. 2019 Oct; 8(10): 1121. 2019 United States Click for
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Pathology Woods, et al. A novel conjugal donor strain for improved DNA transfer into Clostridium spp. Anaerobe. 2019 Oct; 59: 184–191. 2019 United Kingdom Click for
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Pathology Xiao, et al. Modeling the Reduction and Cross-Contamination of Salmonella in Poultry Chilling Process in China Microorganisms. 2019 Oct; 7(10): 448. 2019 China Click for
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Dental Brown, et al. Biofilm-stimulated epithelium modulates the inflammatory responses in co-cultured immune cells Sci Rep. 2019; 9: 15779. 2019 United Kingdom Click for
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Pathology Yu, et al. Beer‐spoilage characteristics of Staphylococcus xylosus newly isolated from craft beer and its potential to influence beer quality Food Sci Nutr. 2019 Dec; 7(12): 3950–3957. 2019 China Click for
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Microbiology Lawson, et al. Breast milk-derived human milk oligosaccharides promote Bifidobacterium interactions within a single ecosystem ISME J. 2020 Feb; 14(2): 635–648. 2020 United Kingdom Click for
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Pathology French, et al. Genomic Analysis of Fluoroquinolone- and Tetracycline-Resistant Campylobacter jejuni Sequence Type 6964 in Humans and Poultry, New Zealand, 2014–2016 Emerg Infect Dis. 2019 Dec; 25(12): 2226–2234. 2019 New Zealand Click for
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Cancer Spiegelberg, et al. Evofosfamide sensitizes esophageal carcinomas to radiation without increasing normal tissue toxicity Radiother Oncol. 2019 Dec; 141: 247–255. 2019 Netherlands Click for
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Microbiology Gui, et l. CytA, a reductase in the cytorhodin biosynthesis pathway, inactivates anthracycline drugs in Streptomyces Commun Biol. 2019; 2: 454. 2019 China Click for
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Dental Ng, et al. The Role of Treponema denticola Motility in Synergistic Biofilm Formation With Porphyromonas gingivalis Front Cell Infect Microbiol. 2019; 9: 432. 2019 Australia Click for
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Microbiology Slade, et al. An in vitro collagen perfusion wound biofilm model; with applications for antimicrobial studies and microbial metabolomics BMC Microbiol. 2019; 19: 310. 2019 United Kingdom Click for
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Pathology Flaujac Lafontaine, et al. Prebiotic Driven Increases in IL-17A Do Not Prevent Campylobacter jejuni Colonization of Chickens Front Microbiol. 2019; 10: 3030. 2019 United Kingdom Click for
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Pathology Van der Veken, et al. Exploring the Ambiguous Status of Coagulase-Negative Staphylococci in the Biosafety of Fermented Meats: The Case of Antibacterial Activity Versus Biogenic Amine Formation Microorganisms. 2020 Feb; 8(2): 167. 2020 Belgium Click for
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