Application Notes for HypOxygen Products

The Importance of Recreating Hypoxic In Vivo Conditions in Mesothelioma Research

April 1, 2026
Written by DWS Microbiologist Kirsty McTear
Click here to view the original article at DWSscientific.com

Mesotheliomas are hyperplastic tumours that cover serosal membranes; more specifically, pleural mesothelioma (PM) is an aggressive form of lung cancer and malignancy of the tumours are often due to asbestos exposure _[1]. Asbestos particles cause recurrent inflammation, generate free radicals and activate protooncogenes, leading to malignant mesothelioma but symptoms usually do not display until 10-50 years post exposure _[1]. Malignant PM has a poor prognosis: most patients are diagnosed with advanced stage disease and have a median survival time of less than 12 months _[2], highlighting the critical need for early detection.

The importance of replicating in vivo conditions

March 8, 2024
Don Whitley Scientific
Click here to link to the orginal article at dwscientific.com

Can cancer researchers benefit from mimicking the body in their labs?

The tumour microenvironment, characterized by low oxygen levels (hypoxia), has been shown to impact cellular processes, including machinery functionality, viability, and gene/protein expression. Understanding the influence of hypoxia, often termed 'tumour physioxia,' is crucial in the research, discovery, and development of oncology treatments. Hypoxia's association with drug resistance and therapeutic inefficacy underscores its importance as a pivotal factor to address in oncological studies and treatment strategies.

The Brain and Hypoxia

July 22,2021
Don Whitley Scientific

brainImage

Being arguably the most important organ in the human body, research into the brain is ever-growing. The World Federation of Neurology hold an annual day dedicated to improving the quality of neurology and brain health _[1]. Research into brain injury is incredibly important, with one of the causes of such injury being hypoxia _[2]. This is because brain cells have a high sensitivity to oxygen, so when cerebral hypoxia occurs, the cells die within minutes causing severe brain damage _[2]. Less severe damage is also observed in tissues surrounding the hypoxic region _[2].

Application Spotlight: Custom GMP Workstation for T Cell Therapy

A custom modular GMP suite of workstations will be used for Cell Therapy. The customer, based in the South of England, is working on a novel new approach to T Cell therapy whereby they are building up a stock of T Cells derived from healthy donors which can be administered to cancer patients.

The system consists of three sections. Section 1 is a H135 HEPA workstation, Section 2 is aH155 GMP workstation, and Section 3 is a refrigerated H135 HEPA workstation. Each section will be attached through a shared airlock.This is represented in the illustration below:

customGMP

A new first in the fight against cancer from Don Whitley Scientific

February 2, 2021

Press Release

2 2 2021DW1

The PRECISE Group at the University of Manchester (pictured above), The Christie NHS Foundation Trust and Don Whitley Scientific today announced the world’s first Proton Radiobiology Modified Atmosphere Workstation with integrated robotic arm, which will be used for research into cancer treatments. The Proton Beam Therapy Centre at The Christie, Manchester, is the first NHS high energy proton beam therapy centre in the UK. Within the facility there is a dedicated research room, which was funded by The Christie Charity, where this new Whitley Workstation will be operated. The workstation with its integrated robotic arm was funded by CRUK Manchester Major Centre funding.