The TC-3 is a simple and multipurpose cell culture bioreactor designed to provide mechanical stimulation to a variety of samples and tissues. The TC-3 is used with:
The TC-3 bioreactor enables users to expose cultures to tension and compression mechanical stimuli. It has been designed to accomodate the needs of cell culture researchers, so only the features of tension machines which are basic for the culture of cells have been included in the TC-3.
Microscopic inspection of cultures is of vital importance for the evaluation of culture status. A simple connector module between the culture chambers and the rest of the TC-s deformation system ensures that the chamber can be easily removed from the system maintaining a desired deformation state while it is taken to the microscope for visual inspection of the culture.
Multiple parallel experiments
Up to three chambers can be actuated simultaneously in the TC-3 bioreactor. The loading conditions are shared by all the chambers, but each chamber can have either a shared or independent nutrient environment.
Horizontal and vertical configurations
The TC-3 can be configured both in horizontal and vertical configurations depending of the type of experiment. Air-liquid interfaces can be obtained with the horizontal configuration for cultures on sheet-like substrates, whereas the vertical configuration is more suitable for tests in which the sample is subjected to compression such as cultures on cylinder-shaped scaffolds.
The TC-3 and TC-3F are controlled by user-definable software to create complex loading profiles to be applied on the culture samples. All the accessory configuration parameters have been removed from the interface, leaving only those which are of interest to be manipulated by the user. A graphical interface allows the user to easily control and check the status of the system without needing to learn to manipulate complex control softwares with a multitude of configuration parameters.