By curating a current list of publications by HypOxystation users, HypOxygen is striving to provide a resource for researchers interested in investigating their cells under truly authentic, physiological culture conditions. Low oxygen, be it hypoxia as a pathological parameter or physioxia as the natural condition for cells, both in vivo and in vitro, is reliably created in the HypOxystation. We hope the science community will find these papers, which are searchable and linked to the original papers, to be useful in elucidating the importance of hypoxic cell culture in their own labs.

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Research Field Authors Title of Paper Citation/Journal Publication Date Country
of Origin
Link to Publication
Stem Cells Llobet et al. Xenobiotics that affect oxidative phosphorylation alter differentiation of human adipose-derived stem cells at concentrations that are found in human blood Disease Models & Mechanisms (2015) 8, 1441-1455 2015 SPAIN Click for
Article
Microbiology Li et al. Improvement of exopolysaccharide production in Lactobacillus caseiLC2W by overexpression of NADH oxidase gene Microbiological Research 171 (2015) 73–77 2015 CHINA Click for
Article
Microbiology Li et al. Isolation and characterization of polycyclic aromatic hydrocarbon-degrading bacteria with tolerance to hypoxic environments Journal of Environmental Science and Health, Part A, 2017 DOI: 10.1080/10934529.2017.1293991 2017 CHINA Click for
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Cardiology Li et al miR-7a/b attenuates post-myocardial infarction remodeling and protects H9c2 cardiomyoblast against hypoxia-induced apoptosis involving Sp1 and PARP-1 Scientific RepoRts 2016 | 6:29082 | DOI: 10.1038/srep29082 2016 CHINA Click for
Article
Cancer Leszczynska et al. Mechanisms and consequences of ATMIN repression in hypoxic conditions: roles for p53 and HIF-1 Scientific Reports 6:21698 2016 2016 UNITED KINGDOM Click for
Article
Hypoxia General Leonard et al. SF2312 is a natural phosphonate inhibitor of enolase Nature Chemical Biology 12, 1053–1058 (2016) 2016 UNITED STATES of AMERICA Click for
Article
Dental Lenzo et al. Determination of Active Phagocytosis of Unopsonized Porphyromonas gingivalis by Macrophages and Neutrophils Using the pH-Sensitive Fluorescent Dye pHrodo Infect Immun 84:1753–1760 2016 AUSTRALIA Click for
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Dental Ledder et al. Bacteriological Effects of Dentifrices with and without Actives of Natural Origin 2014 Appl. Environ. Microbiol. 2014 UNITED KINGDOM Click for
Article
Microbiology Le Marechal et al. Development and Validation of a New Reliable Method for the Diagnosis of Avian Botulism PLoS ONE 12(1): e0169640. 2017 2017 FRANCE Click for
Article
Microbiology Latimer et al. Attenuated Virulence and Biofilm Formation in Staphylococcus aureus following Sublethal Exposure to Triclosan Antimicrob Agents Chemother. 2012 Jun; 56(6): 3092–3100. 2012 UNITED KINGDOM Click for
Article
Dental Latimer et al. Antibacterial and anti-biofilm activity of mouthrinses containing cetylpyridinium chloride and sodium fluoride BMC Microbiology (2015) 15:169 2015 UNITED KINGDOM Click for
Article
Cancer LaChance et al. DNMT3a epigenetic program regulates the HIF-2α oxygen-sensing pathway and the cellular response to hypoxia Proc Natl Acad Sci U S A. 2014 May 27; 111(21): 7783–7788 2014 CANADA Click for
Article
Cancer Labiano et al. Hypoxia-induced soluble CD137 in malignant cells blocks CD137L-costimulation as an immune escape mechanism OncoImmunology Volume 5, Issue 1, 2016 2016 SPAIN Click for
Article
Stroke Kuntz et al. Stroke-induced brain parenchymal injury drives blood–brain barrier early leakage kinetics: a combined in vivo/in vitro study Journal of Cerebral Blood Flow & Metabolism (2014) 34, 95–107 2014 FRANCE Click for
Article
Microbiology Kumar et al. Action of nitroheterocyclic drugs against Clostridium difficile Int J Antimicrob Agents. 2014 October ; 44(4): 314–319 2014 UNITED STATES of AMERICA Click for
Article
Microbiology Kroll et al. Identification of Hypoxia-Inducible Target Genes of Aspergillus fumigatus by Transcriptome Analysis Reveals Cellular Respiration as an Important Contributor to Hypoxic Survival Eucaryotic Cell Volume 13 Number 9 2014 2014 GERMANY Click for
Article
Hypoxia General Koritzinsky Two phases of disulfide bond formation have differing requirements for oxygen JCB 2013 vol. 203 no. 4 615-627 2013 CANADA Click for
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Cancer Knoll et al. Hypoxia regulates TRAIL sensitivity of colorectal cancer cells through mitochondrial autophagy Oncotarget. 2016 Jul 5;7(27):41488-41504 2016 GERMANY Click for
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Hypoxia General Kirmes et al. A transient ischemic environment induces reversible compaction of chromatin Genome Biology 2015 16:246 2015 GERMANY Click for
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Microbiology Kakino et al. Agarwood (Aquilaria Crassna) Extracts Decrease High-protein High-fat Diet-induced Intestinal Putrefaction Toxins in Mice Pharm Anal Acta 2012, 3:3 2012 JAPAN Click for
Article
Hypoxia General Kahlin et al. The human carotid body releases acetylcholine, ATP and cytokines during hypoxia Exp Physiol, 99: 1089–1098 2014 2014 SWEDEN Click for
Article
Stem Cells Jiang et al. HIF1α and CEBP's transcriptionally regulate adipogenic diiferentiation of bone marrow-derived MSC's in hypoxia Stem Cell Research and Therapy 2015, 6:21 2015 CHINA Click for
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Cancer Jiang et al. Hypoxia Potentiates the Radiation-Sensitizing Effect of Olaparib in Human Non-Small Cell Lung Cancer Xenografts by Contextual Synthetic Lethality Int J Radiation Oncol Biol Phys, Vol. 95, No. 2, pp. 772 e781, 2016 2016 UNITED KINGDOM Click for
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Microbiology Jameson et al. Anaerobic choline metabolism in microcompartments promotes growth and swarming of Proteus mirabilis Environ Microbiol. doi:10.1111/1462-2920 2015 2015 UNITED KINGDOM Click for
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Microbiology Iversen The Gut Bacterium Bacteroides thetaiotaomicron Influences the Virulence Potential of the Enterohemorrhagic Escherichia coli O103:H25 PLoS ONE 10(2): e0118140. doi:10.1371 (2015) 2015 NORWAY Click for
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Hypoxia General Huq et al. Propeptide-Mediated Inhibition of Cognate Gingipain Proteinases PLoS ONE. 2013;8(6):e65447 2013 AUSTRALIA Click for
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Cancer Hunter et al. Hypoxia-activated prodrugs: paths forward in the era of personalised medicine Br J Cancer. 2016 May 10; 114(10): 1071–1077. 2016 UNITED STATES of AMERICA & NEW ZEALAND Click for
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Cancer Humtsoe et al. ErbB3 upregulation by the HNSCC 3D microenvironment modulates cell survival and growth Oncogene 35, 1554-1564 (24 March 2016) 2016 UNITED STATES of AMERICA Click for
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Dental Holcombe et al. Early Canine Plaque Biofilms: Characterization of Key Bacterial Interactions Involved in Initial Colonization of Enamel PLoS ONE 9(12): e113744 2014 2014 UNITED KINGDOM Click for
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Hypoxia General Ho et al. Systemic Reprogramming of Translation Efficiencies on Oxygen Stimulus Cell Reports 14, 1293–1300 February 16, 2016 2016 UNITED STATES of AMERICA Click for
Article
Microbiology Hidalgo-Cantabrana et al. Effect of a Ropy Exopolysaccharide-Producing Bifidobacterium animalis subsp. lactis Strain Orally Administered on DSS-Induced Colitis Mice Model Front Microbiol. 2016; 7: 868. 2016 SPAIN Click for
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Cancer Hevia et al. Human colon-derived soluble factors modulate gut microbiota composition Front. Oncol. 5:86. 2015 2015 SPAIN Click for
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Cancer Herzog et al. Cyclin-dependent kinase 5 stabilizes hypoxia-inducible factor-1α: a novel approach for inhibiting angiogenesis in hepatocellular carcinoma Oncotarget. 2016 May 10; 7(19): 27108–27121 2016 GERMANY Click for
Article
Cancer Herrmann et al. Cellular memory of hypoxia elicits neuroblastoma metastasis and enables invasion by non-aggressive neighbouring cells. Oncogenesis. 2015 Feb; 4(2): e138. 2015 UNITED KINGDOM Click for
Article
Cancer Hansson et al. Overexpression of functional SLC6A3 in clear cell renal cell carcinoma Clin Cancer Res. 2016 Sep 23 2016 SWEDEN Click for
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Microbiology Handley et al. PerR controls oxidative stress defence and aerotolerance, but not motility-associated phenotypes of Campylobacter jejuni Microbiology July 2015 161: 1524-1536 2015 UNITED KINGDOM Click for
Article
Cancer Hamidian et al. Differential regulation of HIF-1a and HIF-2a in neuroblastoma: Estrogen-related receptor alpha (ERRa) regulates HIF2A transcription and correlates to poor outcome Biochemical and Biophysical Research Communications 461 (2015) 560 -567 2015 SWEDEN Click for
Article
Neurology Haile et al. Tissue-type plasminogen activator has a neuroprotective effect in the ischemic brain mediated by neuronal TNF-α J Cereb Blood Flow Metab. 2012 Jan; 32(1): 57–69 2012 UNITED STATES of AMERICA Click for
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Cancer Hai et al. TRIM14 is a Putative Tumor Suppressor and Regulator of Innate Immune Response in Non-Small Cell Lung Cancer Scientific Reports 7, Article number: 39692 (2017) 2017 CANADA Click for
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Microbiology Gundogdu et al. The Campylobacter jejuni Oxidative Stress Regulator RrpB Is Associated with a Genomic Hypervariable Region and Altered Oxidative Stress Resistance Front Microbiol. 2016; 7: 2117. 2016 UNITED STATES of AMERICA Click for
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Microbiology Gundogdu et al. The Campylobacter jejuni MarR-like transcriptional regulators RrpA and RrpB both influence bacterial responses to oxidative and aerobic stresses Front. Microbiol., 21 July 2015 2015 UNITED KINGDOM Click for
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Microbiology Gundogdu The Campylobacter jejuni Transcriptional Regulator Cj1556 Plays a Role in the Oxidative and Aerobic Stress Response and Is Important for Bacterial Survival In Vivo J Bacteriol. 2011 Aug; 193(16): 4238–4249 2011 UNITED KINGDOM Click for
Article
Microbiology Grosu-Tudor et al. Prebiotic potential of some exopolysaccharides produced by lactic acid bacteria Romanian Biotechnological Letters, Vol. 18, No. 5, 2013 2013 ROMANIA Click for
Article
Dental Gorman Structure of the lysine specific protease Kgp from Porphyromonas gingivalis, a target for improved oral health Protein Sci. 2015 Jan; 24(1): 162–166 2015 AUSTRALIA Click for
Article
Cardiology González-Santamaría Matrix cross-linking lysyl oxidases are induced in response to myocardial infarction and promote cardiac dysfunction Cardiovasc Res. 2016 Jan 1;109(1):67-78 2016 SPAIN Click for
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Cancer Gomez-Maldonado et al. EFNA3 long noncoding RNAs induced by hypoxia promote metastatic dissemination Oncogene (2014), 1–12 2014 SPAIN Click for
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Hypoxia General Garcia-Bermudez PKA Phosphorylates the ATPase Inhibitory Factor 1 and Inactivates Its Capacity to Bind and Inhibit the Mitochondrial H +-ATP Synthase Cell Reports 12, 2143–2155 2015 2015 SPAIN Click for
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Microbiology Forbes et al. Formulation of Biocides Increases Antimicrobial Potency 2 and Mitigates the Enrichment of Non-Susceptible 3 Bacteria in Multi-Species Biofilms Appl Environ Microbiol. 2017 Jan 23. pii: AEM.03054-16. 2017 UNITED KINGDOM Click for
Article
Dental Forbes et al. Simultaneous Assessment of Acidogenesis- Mitigation and Specific Bacterial Growth- Inhibition by Dentifrices PLOS ONE 11(2) DOI:10.1371/journal.pone.0149390 February 16, 2016 2016 UNITED KINGDOM Click for
Article
Microbiology Fontenete et al. Fluorescence In Vivo Hybridization (FIVH) for Detection of Helicobacter pylori Infection in a C57BL/6 Mouse Model PLoS ONE 11(2): e0148353 2016 2016 PORTUGAL Click for
Article
Cancer Flett et al. Gulonolactone Addition to Human Hepatocellular Carcinoma Cells with Gene Transfer of Gulonolactone Oxidase Restores Ascorbate Biosynthesis and Reduces Hypoxia Inducible Factor 1 Biomedicines 2014, 2(1), 98-109 2014 NEW ZEALAND Click for
Article
Cancer Fitzgerald et al. Nox4 Mediates Renal Cell Carcinoma Cell Invasion through Hypoxia-Induced Interleukin 6- and 8- Production PLoS One. 2012; 7(1): e30712 2012 UNITED STATES of AMERICA Click for
Article
Cancer Fernandez-Barral Hypoxia Negatively Regulates Antimetastatic PEDF in Melanoma Cells by a Hypoxia Inducible Factor-Independent, Autophagy Dependent Mechanism. PLoS ONE 2012; 7(3): e32989. 2012 SPAIN Click for
Article
Stem Cells Fan et al. Local renin-angiotensin system regulates hypoxia-induced vascular endothelial growth factor synthesis in mesenchymal stem cells Int J Clin Exp Pathol 2015;8(3):2505-2514 2015 CHINA Click for
Article
Microbiology Elmi et al. Campylobacter jejuni outer membrane vesicle-associated proteolytic activity promotes bacterial invasion by mediating cleavage of intestinal epithelial cell E-cadherin and occludin Cell Microbiol. 2016 Apr;18(4):561-72. 2016 UNITED KINGDOM Click for
Article
Stem Cells Elmadbouh et al. Preconditioning of Human Skeletal Myoblast with Stromal Cell-derived Factor-1Ձ Promotes Cytoprotective Effects against Oxidative and Anoxic Stress Int J Stem Cells 2011;4:50-60 2011 FRANCE Click for
Article
Cancer Elkashef et al. Polysialic acid sustains cancer cell survival and migratory capacity in a hypoxic environment Nature Scientific Reports 2016 6:33026 2016 UNITED KINGDOM Click for
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Microbiology Elahi et al. Immunosuppressive CD71+ erythroid cells compromise neonatal host defence against infection Nature 504,158–162 2013 2013 UNITED STATES of AMERICA Click for
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Neurology Echeverry et al. The cytokine tumor necrosis factor-like weak inducer of apoptosis and its receptor fibroblast growth factor-inducible 14 have a neuroprotective effect in the central nervous system Journal of Neuroinflammation 2012, 9:45 2012 UNITED STATES of AMERICA Click for
Article
Cancer Eales et al. Hypoxia and metabolic adaptation of cancer cells Oncogenesis (2016) 5 2016 UNITED KINGDOM Click for
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Dental Downes et al Description of Alloprevotella rava gen. nov., sp. nov., isolated from the human oral cavity, and reclassification of Prevotella tannerae International Journal of Systematic and Evolutionary Microbiology (2013), 63, 1214–1218 2013 UNITED KINGDOM Click for
Article
Cancer Doherty et al. Photodynamic killing of cancer cells by a Platinum(II) complex with cyclometallating ligand Nature Scientific Reports 6:22668 2016 2016 UNITED KINGDOM Click for
Article
Cancer Djidja et al. Identification of Hypoxia-Regulated Proteins Using MALDI-Mass Spectrometry Imaging Combined with Quantitative Proteomics J. Proteome Res., 2014, 13 (5), pp 2297–2313 2014 UNITED KINGDOM Click for
Article
Cancer Dixon et al. Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis eLife 2014;3:e02523 2014 UNITED STATES of AMERICA Click for
Article
Cancer del Poggetto et al. Salarin C inhibits the maintenance of chronic myeloid leukemia progenitor cells Cell Cycle, Vol. 14, Iss. 19, 2015 2015 ITALY Click for
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Microbiology Dekio et al. Genetic diversity of Propionibacterium acnes strains isolated from human skin in Japan and comparison with their distribution in Europe Journal of Medical Microbiology (2012), 61, 622–630 2012 JAPAN Click for
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Microbiology de Sordi et al. Development of Photodynamic Antimicrobial Chemotherapy (PACT) for Clostridium difficile PLoS ONE 10(8): e0135039. doi:10.1371/journal.pone.0135039 (2015) 2015 UNITED KINGDOM Click for
Article
Neurology de Bruin et al. Genome-wide analysis reveals NRP1 as a direct HIF1α-E2F7 target in the regulation of motorneuron guidance in vivo Nucl. Acids Res. first published online December 17, 2015 2015 NETHERLANDS Click for
Article
Dental Davis et al. The Unculturables: targeted isolation of bacterial species associated with canine periodontal health or disease from dental plaque BMC Microbiol. 2014; 14: 196 2014 UNITED KINGDOM Click for
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Cancer Cronin et al. High Resolution In Vivo Bioluminescent Imaging for the Study of Bacterial Tumour Targeting PLoS ONE 7(1): e30940 2012 2012 IRELAND Click for
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Cancer Cox et al. The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase Nature 522, 106–110 2015 2015 UNITED KINGDOM Click for
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Cancer Cox et al. Dataset for the proteomic inventory and quantitative analysis of the breast cancer hypoxic secretome associated with osteotropism Data in Brief 5 (2015) 621-625 2015 UNITED KINGDOM Click for
Article
Microbiology Costabile et al. Impact of polydextrose on the faecal microbiota: a double-blind, crossover, placebo-controlled feeding study in healthy human subjects British Journal of Nutrition (2012), 108, 471–481 2012 UNITED KINGDOM Click for
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Microbiology Corcionivoschi et al. Virulence characteristics of hcp+Campylobacter jejuni and Campylobacter coli isolates from retail chicken Gut Pathog. 2015 Jul 24;7:20. 2015 UNITED KINGDOM Click for
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Cancer Collet et al. Endothelial precursor cell-based therapy to target the pathologic angiogenesis and compensate tumor hypoxia Cancer Letters 370 (2016) 345–357 2016 POLAND Click for
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Microbiology Clohessy et al. Severity and frequency of community-onset Clostridium difficile infection on an Australian tertiary referral hospital campus International Journal of Infectious Diseases 29 (2014) 152–155 2014 AUSTRALIA Click for
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Microbiology Cherian et al. Chemical Modulation of the Biological Activity of Reutericyclin: a Membrane-Active Antibiotic from Lactobacillus reuteri Sci Rep. 2014; 4: 4721 2014 UNITED STATES of AMERICA Click for
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Microbiology Cherian et al. Gastrointestinal localization of metronidazole by a lactobacilli-inspired tetramic acid motif improves treatment outcomes in the hamster model of Clostridium difficile infection J Antimicrob Chemother 2015; 70: 3061–3069 2015 UNITED STATES of AMERICA Click for
Article
Cardiology Castellano et al. Hypoxia Stimulates Low-Density Lipoprotein Receptor–Related Protein-1 Expression Through Hypoxia-Inducible Factor-1 in Human Vascular Smooth Muscle Cells Arterioscler Thromb Vasc Biol. 2011;31:1411-1420 2011 SPAIN Click for
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Microbiology Carvalho et al. Antimicrobial Activity of Diterpenes from Viguiera arenaria against Endodontic Bacteria Molecules 2011, 16(1), 543-551 2011 BRAZIL Click for
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Diabetes & Obesity Carson et al. The Rab11 Effector Protein FIP1 Regulates Adiponectin Trafficking and Secretion 2013 PLoS ONE 8(9): e74687. doi:10.1371/journal.pone.0074687 2013 UNITED KINGDOM Click for
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Cancer Campbell et al. Ascorbate availability affects tumor implantation-take rate and increases tumor rejection in Gulo–/– mice Hypoxia 2016:4 41–52 2016 NEW ZEALAND Click for
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Dental Calil et al. Effects of stress hormones on the production of volatile sulfur compounds by periodontopathogenic bacteria. Braz Oral Res. 2014;28 2014 BRAZIL Click for
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Cardiology Cal et al. Low-density lipoprotein receptor-related protein 1 mediates hypoxia-induced very low density lipoprotein-cholesteryl ester uptake and accumulation in cardiomyocytes Cardiovascular Research (2012) 94 , 469–479 2012 SPAIN Click for
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Stem Cells Cai et al. Hypoxic Conditioned Medium from Rat Cerebral Cortical Cells Enhances the Proliferation and Differentiation of Neural Stem Cells Mainly through PI3-K/Akt Pathways PLoS One November 2014; Volume 9; Issue 11; e111938 2014 CHINA Click for
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Microbiology Cadnum et al. Sensitive and Selective Culture Medium for Detection of Environmental Clostridium difficile Isolates without Requirement for Anaerobic Culture Conditions J. Clin. Microbiol. September 2014 vol. 52 no. 9 3259-3263 2014 UNITED KINGDOM Click for
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Dental Butler et al. The Porphyromonas gingivalis Ferric Uptake Regulator Orthologue Binds Hemin and Regulates Hemin-Responsive Biofilm Development PLoS One. 2014; 9(11): e111168 2014 AUSTRALIA Click for
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Cancer Burrows et al. Hypoxia-induced nitric oxide production and tumour perfusion is inhibited by pegylated arginine deiminase (ADI-PEG20) Scientific Reports 6, Article number: 22950 2016 2016 UNITED KINGDOM Click for
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Hypoxia General Burr et al. Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1a Stability in Aerobic Conditions Cell Metabolism 25, 740–752, November 8, 2016 2016 UNITED KINGDOM Click for
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Dental Burmistrz et al. Functional Analysis of Porphyromonas gingivalis W83 CRISPR-Cas Systems J Bacteriol 197:2631–2641 2015 2015 POLAND Click for
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Hypoxia General Bremm et al. Cezanne (OTUD 7 B) regulates HIF-1a homeostasis in a proteasome-independent manner EMBO reports Vol 15 No 12, 2014 2014 GERMANY Click for
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Dental Biederman et al Interactions of anaerobic bacteria with dental stem cells: an In Vitro study PLoS ONE 9(11): e110616 2014 2014 GERMANY Click for
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Cancer Banh et al. PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia Nature Cell Biology 18, 803–813 (2016) 2016 UNITED STATES of AMERICA Click for
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Cancer Baker et al. The HIF-pathway inhibitor NSC-134754 induces metabolic changes and anti-tumour activity while maintaining vascular function British Journal of Cancer (2012) 106, 1638–1647 2012 UNITED KINGDOM Click for
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Hypoxia General Bagnall et al. Tight Control of Hypoxia-inducible Factor-α Transient Dynamics Is Essential for Cell Survival in Hypoxia The Journal of Biological Chemistry. 2014;289(9):5549-5564. 2014 UNITED KINGDOM Click for
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Neurology Audas et al. Adaptation to Stressors by Systemic Protein Developmental Cell 39, 155–168, October 24, 2016 2016 UNITED STATES of AMERICA Click for
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Cancer Asby et al. Triggering apoptosis in cancer cells with an Org. Biomol. Chem., 2016 2016 UNITED KINGDOM Click for
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Stem Cells Al-Lamki et al. TNF, Acting Through Inducibly Expressed TNFR2, Drives Activation and Cell Cycle Entry of c-Kit 1 Cardiac Stem Cells in Ischemic Heart Disease STEM CELLS 2013;31:1881–1892 2013 UNITED KINGDOM Click for
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Microbiology Alam et al. Mode of Action and Bactericidal Properties of Surotomycin against Growing and Nongrowing Clostridium difficile Antimicrob Agents Chemother. 2015 Sep; 59(9): 5165–5170 2015 UNITED STATES of AMERICA Click for
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Cancer Alam et al. HIF2α contributes to antiestrogen resistance via positive bilateral Oncotarget 2016, Vol. 7, No. 10 2016 SWEDEN Click for
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