Hypoxia and the Hallmarks of Cancer
from HypOxygen

HallmarksHypoxiaWeb

The Hallmarks of Cancer are directly affected, and in many cases even caused, by hypoxia as a defining feature of tumors. Oxygen in the tumor microenvironment and within the cells is central to metabolism, immunology, epigenetics and therapy resistance of all the cancers. The recent review by HypOxystation users Wigerup and Pahlman illustrates how "tumor hypoxia affects most of the Cancer Hallmarks".* Cell culture at very low oxygen in the HypOxystation mimics the in vivo conditions encountered by cancer cells. The HypOxystation hypoxia workstation enables glove-less access to cultivate and manipulate cells under physio- logical conditions, in a HEPA- clean environment.

* "Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer" Pharmacology & Therapeutics 164 (2016)

Why Choose the HypOxystation for Cancer Research Applications

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Choose Your Cell Culture Environment

Specifically designed to create normoxic, hypoxic and anoxic conditions within a controlled and sustained workstation environment. This hypoxic incubator is ideal for research requiring the ability to accurately control O₂, CO₂, temperature and humidity. Application possibilities for HypOxystation are endless; it is being used for research into tumor microenvironment, hypoxia pathways and HIF signaling, in vitro modeling of in situ environments, cancer cell metastasis, angiogenesis, and many other fields where cells may benefit from a physiological atmosphere.

Features

- Control O₂ in 0.1% increments from 0.1% - 20%

- Control CO₂ in 0.1% increments from 0.1% - 15%

- Control relative humidity up to 90%

- Control temperature easily and precisely

- Touch screen interface to monitor all parameters simultaneously

- Straightforward calibration of gas sensors without removing sensors from the chamber or disrupting the working atmosphere

- Real time feedback system monitors and adjusts O₂ levels to insure accuracy; CO₂ feedback is also available

- Eight size models to choose from to meet your research needs

Click here for more information on the HypOxystation

What Our Users Are Saying

Our lab has been working for many years in understanding the mechanisms by which components of the microenvironment (e.g. hypoxia, low nutrient availability) interact with cellular survival/apoptotic pathways to produce a more resistant tumor phenotype. Also, we have extensively studied ways to increase the therapeutic effectiveness of ionizing radiation (IR) by either employing existing compounds with relatively safe toxicity profiles or employ screening strategies to identify novel and potent radiation sensitizers. Since many of our studies involve hypoxic conditions, we rely a lot on the hypoxic chamber. We have recently replaced our old hypoxic station with the HypOxystation® H35. We found the new station as incredible and reliable equipment for our studies. We can easily control and maintain the O2 and CO2 concentrations and humidity at the desired levels without consuming tons of gas supplies as we used to do in the past. It is also very ergonomic and user-friendly through the touchscreen interface.

Ioannis Verginadis, PhD
Department of Radiation Oncology
Univ. of Pennsylvania Perelman School of Medicine, PA, USA
We love the HypOxystation® system. In fact, we just got a publication accepted using this machine. Right now, we have two groups that use the workstation regularly. We love it.

Dr. Patrick Frost
Dept of Hematology-Oncology
VA Greater Los Angeles Healthcare System, USA
Without tightly controlled oxygen tension, experimental design is not as robust as it should be. Our HypOxystation® opens up more experiments to us and gives us confidence in the data generated.

Dr. Roger Phillips
Institute of Cancer Therapeutics
University of Bradford, England
We have used three HypOxystations® for about two years now to investigate the role of hypoxia in tumor microenvironments. They are running constantly without any problems. With the results being generated, and the demand for their use, we have now purchased a fourth instrument.

Dr. Bradley Wouters
Ontario Cancer Institute, Canada
In the past, we used an incubator for our hypoxia work but we saw fluctuations in the gene expression patterns from one set of assays to the next, so we couldn’t rely on the results. We see a strong consistency in the results obtained with the HypOxystation.

Dr. Houda Benlhabib
UT Southwestern, Dallas, TX, USA

HypOxygen Supports Research

Researcher Travel Grants

Our annual research travel grants are allocated for HypOxystation users and allows receipients to attend conferences, take colleagues, attend meetings and tradeshows, be a keynote speaker, the possibilities are endless! Here are our past recipients:

2020

Serina Cheung is currently a second year MSc student in Dr. Marianne Koritzinsky’s lab. She is investigating the role of p38 mitogen-activation protein kinase in promoting the survival of castration-resistant prostate cancer under hypoxia.

Ronald Wu is a PhD candidate in Dr. Brad Wouters lab at the University of Toronto and is investigating the role of hypoxia on oxygen-dependent DNA and histone demethylases in glioblastoma. Specifically, he is interested in the epigenetic mechanisms governing self-renewal and differentiation in this deadly brain tumour.

Sandy Lee is a third year PhD student in Dr. Marianne Koritzinsky’s lab within the Institute of Medical Science at the University of Toronto. She is investigating how different levels of oxygen can mediate the folding process of a protein. She is interested in proteins that cause aggressive cancer phenotypes.

Stephanie Hulme is currently a second year MSc student in Dr. Marianne Koritzinsky’s lab. She is investigating protein secretion rates of VEGF and CA9 under normoxic and anoxic oxygen conditions.

2019

Dan Cojocari and Elizabeth Koch of the Princess Margaret Cancer Centre in Toronto, Canada. The authors, who grow their cell cultures at very low oxygen in the HypOxystation, presented their findings, "Autophagy Promotes Tolerance to Hypoxia through Maintenance of Metabolic Homeostasis" at the 14th International Wolfsberg Meeting on Molecular Radiation Biology & Oncology in Switzerland.

CellPress Cancer Research Week

HypOxygen and Don Whitley Scientific are proud to support CellPress in their efforts to provide research information and relevant panel discussions in lieu of conferences and tradeshows for 2020.

The Cancer Research Hub can be accessed here

CellPress Selections: Hypoxia in Cancer

HypOxygen and Don Whitley Scientific have teamed up with Cell Press to provide you with the latest research articles involving hypoxia and cancer. The articles compiled in this reprint collection showcase current progress in hypoxia in cancer—from an intravital imaging approach to monitor hypoxic regions in pancreatic cancer to a proposed combination therapy using an antiangiogenic drug to induce hypoxia with a drug targeting lipid metabolism. You can download them here for FREE!

Click Here to Download

Publications

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Research Field	Authors	Title of Paper	Citation/Journal	Publication Date	Country of Origin	Link to Publication
Cancer	Niu et al.	BRD7 inhibits the Warburg effect and tumor progression through inactivation of HIF1α/LDHA axis in breast cancer	Cell Death Dis. 2018 May; 9(5): 519.	2018	CHINA	Click for Article
Cancer	Chhipa et al.	AMP Kinase Promotes Glioblastoma Bioenergetics and Tumor Growth	Nat Cell Biol. Author manuscript; available in PMC 2018 Dec 18.	2018	UNITED STATES of AMERICA	Click for Article
Cancer	Hermann et al.	Magnetic Resonance Imaging for Characterization of a Chick Embryo Model of Cancer Cell Metastases	Mol Imaging. 2018 Jan-Dec; 17: 1536012118809585.	2018	UNITED KINGDOM	Click for Article
Cancer	Wohlrab et al.	The Association Between Ascorbate and the Hypoxia-Inducible Factors in Human Renal Cell Carcinoma Requires a Functional Von Hippel-Lindau Protein	Front Oncol. 2018; 8: 574.	2018	NEW ZEALAND	Click for Article
Cancer	Cao et al.	miR-18a reactivates the Epstein-Barr virus through defective DNA damage response and promotes genomic instability in EBV-associated lymphomas	BMC Cancer. 2018; 18: 1293.	2018	CHINA	Click for Article
Cancer	Jamieson et al.	Evofosfamide for the treatment of human papillomavirus-negative head and neck squamous cell carcinoma	JCI Insight. 2018 Aug 23; 3(16): e122204.	2018	NEW ZEALAND	Click for Article
Cancer	Al-Mutawa et al.	Effects of hypoxic preconditioning on neuroblastoma tumour oxygenation and metabolic signature in a chick embryo model	Biosci Rep. 2018 Aug 31; 38(4): BSR20180185.	2018	UNITED KINGDOM	Click for Article
Cancer	Eales et al.	Verteporfin selectively kills hypoxic glioma cells through iron-binding and increased production of reactive oxygen species	Sci Rep. 2018; 8: 14358.	2018	UNITED KINGDOM	Click for Article
Cancer	Ho et al.	Systemic reprograming of translation efficiencies on oxygen stimulus	Cell Rep. Author manuscript; available in PMC 2016 Mar 9.	2016	UNITED STATES of AMERICA	Click for Article
Cancer	Gammoh et al.	Suppression of autophagy impedes glioblastoma development and induces senescence	Autophagy. 2016; 12(9): 1431–1439.	2016	UNITED KINGDOM	Click for Article
Cancer	Leszczynska, et al.	Preclinical testing of an Atr inhibitor demonstrates improved response to standard therapies for esophageal cancer	Radiother Oncol. 2016 Nov; 121(2): 232–238.	2016	UNITED KINGDOM	Click for Article
Cancer	O'Connor et al.	CYP450 Enzymes Effect Oxygen-Dependent Reduction of Azide-Based Fluorogenic Dyes	ACS Cent Sci. 2017 Jan 25; 3(1): 20–30.	2017	UNITED KINGDOM	Click for Article
Cancer	Labiano et al.	CD69 is a direct HIF-1α target gene in hypoxia as a mechanism enhancing expression on tumor-infiltrating T lymphocytes	Oncoimmunology. 2017; 6(4): e1283468.	2017	SPAIN	Click for Article
Cancer	Wadkin et al.	CD151 supports VCAM-1-mediated lymphocyte adhesion to liver endothelium and is upregulated in chronic liver disease and hepatocellular carcinoma	Am J Physiol Gastrointest Liver Physiol. 2017 Aug 1; 313(2): G138–G149.	2017	UNITED KINGDOM	Click for Article
Cancer	Poupard et al.	Assessment of Heparanase-Mediated Angiogenesis Using Microvascular Endothelial Cells: Identification of λ-Carrageenan Derivative as a Potent Anti Angiogenic Agent	Mar Drugs. 2017 May; 15(5): 134.	2017	FRANCE	Click for Article
Cancer	Dobrynin et al.	KDM4A regulates HIF-1 levels through H3K9me3	Sci Rep. 2017; 7: 11094.	2017	UNITED KINGDOM	Click for Article
Cancer	Kelly et al.	Hypoxia activates cadherin-22 synthesis via eIF4E2 to drive cancer cell migration, invasion and adhesion	Oncogene. Author manuscript; available in PMC 2018 Feb 6.	2018	CANADA	Click for Article
Cancer	Krawczyk et al.	Injury induced expression of caveolar proteins in human kidney tubules - role of megakaryoblastic leukemia 1	BMC Nephrol. 2017; 18: 320.	2017	SWEDEN	Click for Article
Cancer	Paredes et al.	Poldip2 is an oxygen-sensitive protein that controls PDH and αKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer	Proc Natl Acad Sci U S A. 2018 Feb 20; 115(8): 1789–1794.	2018	UNITED STATES of AMERICA	Click for Article
Cancer	Chandrashekhar et al.	Transducer like proteins of Campylobacter jejuni 81-176: role in chemotaxis and colonization of the chicken gastrointestinal tract	Front Cell Infect Microbiol. 2015; 5: 46.	2015	UNITED STATES of AMERICA	Click for Article
Cancer	Stivarou et al.	The complex metabolic network gearing the G1/S transition in leukemic stem cells: Hints to a rational use of antineoplastic agents	Oncotarget. 2015 Oct 13; 6(31): 31985–31996.	2015	ITALY	Click for Article
Cancer	Yu et al.	Berberine may rescue Fusobacterium nucleatum-induced colorectal tumorigenesis by modulating the tumor microenvironment	Oncotarget. 2015 Oct 13; 6(31): 32013–32026.	2015	CHINA	Click for Article
Cancer	Cheloni et al.	The Leukemic Stem Cell Niche: Adaptation to “Hypoxia” versus Oncogene Addiction	Stem Cells Int. 2017; 2017: 4979474.	2017	ITALY	Click for Article
Cancer	Yu et al.	Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy	Cell. Author manuscript; available in PMC 2018 Jan 13.	2017	CHINA	Click for Article
Cancer	Sordi et al.	Development of Photodynamic Antimicrobial Chemotherapy (PACT) for Clostridium difficile	PLoS One. 2015; 10(8): e0135039.	2015	UNITED KINGDOM	Click for Article
Cancer	Rodenhizer et al.	A 3D engineered tumour for spatial snap-shot analysis of cell metabolism and phenotype in hypoxic gradients	Nat Mater. 2016 Feb; 15(2): 227–234.	2016	UNITED KINGDOM	Click for Article
Cancer	Olivares et al.	Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions	Nat Commun. 2017; 8: 16031.	2017	FRANCE	Click for Article
Cancer	Almodares et al.	Rhodium, Iridium, and Ruthenium Half-Sandwich Picolinamide Complexes as Anticancer Agents	Inorg. Chem., 2014, 53 (2), pp 727–736	2014	UNITED KINGDOM	Click for Article
Cancer	Padro et al.	Genome-independent hypoxic repression of estrogen receptor alpha in breast cancer cells	BMC Cancer (2017) 17:203	2017	UNITED STATES of AMERICA	Click for Article
Cancer	Meehan et al.	Inhibition of pH regulation as a therapeutic strategy in hypoxic human breast cancer cells	Oncotarget. 2017 Jun 27;8(26):42857-42875	2017	UNITED KINGDOM	Click for Article
Cancer	Bulusu et al.	Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation	Cell Reports 18, 647–658 (2017)	2017	UNITED KINGDOM	Click for Article
Cancer	Kalenderoglou et al.	Cannabidiol Reduces Leukemic Cell Size – But Is It Important?	Front. Pharmacol. 8:144 (2017)	2017	UNITED KINGDOM	Click for Article
Cancer	Lord et al.	Hypoxia Sensitive Metal #-Ketoiminate Complexes Showing Induced Single Strand DNA Breaks and Cancer Cell Death by Apoptosis	J. Med. Chem., 2015, 58 (12), pp 4940–4953	2015	UNITED KINGDOM	Click for Article
Cancer	O'Connor et al.	Design, synthesis and evaluation of molecularly targeted hypoxia-activated prodrugs	Nature Protocols 11, 781–794 (2016)	2016	UNITED KINGDOM	Click for Article
Cancer	Horemans et al.	In-vivo evaluation of apocynin for prevention of Helicobacter pylori-induced gastric carcinogenesis	Eur J Cancer Prev. 2017 Jan;26(1):10-16.	2017	BELGIUM	Click for Article
Cancer	Thoren et al.	Myc-induced glutaminolysis bypasses HIF-driven glycolysis in hypoxic small cell lung carcinoma cells	Oncotarget, 2017, Vol. 8, (No. 30), pp: 48983-48995	2017	SWEDEN	Click for Article
Cancer	Chen et al.	Autophagy enhanced the radioresistance of nonsmall cell lung cancer by regulating ROS level under hypoxia condition	International Journal of Radiation Biology, 2017 DOI: 10.1080/09553002.2017.1325025	2017	CHINA	Click for Article
Cancer	Cheloni et al.	Targeting chronic myeloid leukemia stem cells with the hypoxia-inducible factor inhibitor acriflavine	Blood 2017 :blood-2016-10-745588	2016	ITALY	Click for Article
Cancer	Xintaropoulou et al.	A comparative analysis of inhibitors of the glycolysis pathway in breast and ovarian cancer cell line models	Oncotarget, Vol. 6, No. 28 2015	2015	UNITED KINGDOM	Click for Article
Cancer	Wilson et al.	Hypoxia inducible factors in liver disease and hepatocellular carcinoma: Current understanding and future directions	Journal of Hepatology 2014 vol. 61, 1397–1406	2014	UNITED KINGDOM	Click for Article
Cancer	Wigerup et al.	Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer	Pharmacology & Therapeutics; Vol. 164, August 2016, Pages 152–169	2016	SWEDEN	Click for Article
Cancer	Wennemers et al.	Regulation of TRIB3 mRNA and Protein in Breast Cancer	PLoS ONE 7(11):e49439 2012	2012	NETHERLANDS	Click for Article
Cancer	Wennemers et al.	Tribbles homolog 3 denotes a poor prognosis in breast cancer and is involved in hypoxia response	BreastCancerResearch 2011, 13:R82	2011	NETHERLANDS	Click for Article
Cancer	Weiss et al.	Palladium-Mediated Dealkylation of N-Propargyl-Floxuridine as a Bioorthogonal Oxygen-Independent Prodrug Strategy	SCIENTIFIC REPORTS 5 : 9329 2015	2015	UNITED KINGDOM	Click for Article
Cancer	Ward et al.	Evaluation of carbonic anhydrase IX as a therapeutic target for inhibition of breast cancer invasion and metastasis using a series of in vitro breast cancer models	Oncotarget. 2015;6(28):24856-24870.	2015	UNITED KINGDOM	Click for Article
Cancer	van den Beucken et al.	Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER	Nature Communications 5, Article number: 5203 2014	2014	UNITED STATES of AMERICA	Click for Article
Cancer	van de Schootbrugge et al.	αB-crystallin stimulates VEGF secretion and tumor cell migration and correlates with enhanced distant metastasis in head and neck squamous cell carcinoma	MCCancer 2013, 13:128	2013	NETHERLANDS	Click for Article
Cancer	van de Schootbrugge et al.	Effect of hypoxia on the expression of αB-crystallin in head and neck squamous cell carcinoma	BMC Cancer(2014)14:252	2014	NETHERLANDS	Click for Article
Cancer	Vaapil et al.	Hypoxic Conditions Induce a Cancer-Like Phenotype in Human Breast Epithelial Cells	PLoS ONE 7(9): e46543. doi:10.1371 (2012)	2012	SWEDEN	Click for Article
Cancer	Uniacke et al.	Cancer cells exploit eIF4E2-directed synthesis of hypoxia response proteins to drive tumor progression	Cancer Res. 2014 Mar 1;74(5):1379-89	2014	CANADA	Click for Article
Cancer	Tan et al.	Role of Autophagy as a Survival Mechanism for Hypoxic Cells in Tumors	Neoplasia (2016) 18, 347–355	2016	CANADA	Click for Article
Cancer	Sun et al.	Hypoxic Regulation of Glutamine Metabolism through HIF1 and SIAH2 Supports Lipid Synthesis that Is Necessary for Tumor Growth	Cell Metab. 2014 February 4; 19(2): 285–292	2014	UNITED STATES of AMERICA	Click for Article
Cancer	Stegeman et al.	Activation of AKT by hypoxia: a potential target for hypoxic tumors of the head and neck	BMCCancer 2012, 12:463	2012	NETHERLANDS	Click for Article
Cancer	Stegeman et al.	Interaction between hypoxia, AKT and HIF-1 signaling in HNSCC and NSCLC: implications for future treatment strategies	Future Sci. OA (2016) 2(1), FSO84 2016	2016	NETHERLANDS	Click for Article
Cancer	Starmans et al.	The prognostic value of temporal in vitro and in vivo derived hypoxia gene-expression signatures in breast cancer	Radiotherapy and Oncology 102 (2012) 436–443	2012	NETHERLANDS	Click for Article
Cancer	Sonke et al.	Inhibition of endogenous hydrogen sulfide production in clear-cell renal cell carcinoma cell lines and xenografts restricts their growth, survival and angiogenic potential	Nitric Oxide 49 (2015) 26-39	2015	CANADA	Click for Article
Cancer	Škrtić et al.	INHIBITION OF MITOCHONDRIAL TRANSLATION AS A THERAPEUTIC STRATEGY FOR HUMAN ACUTE MYELOID LEUKEMIA	Cancer cell. 2011;20(5):674-688.	2011	CANADA	Click for Article
Cancer	Schaaf et al.	The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia	Radiotherapy and Oncology 108 (2013) 529–534	2013	NETHERLANDS	Click for Article
Cancer	Satani et al.	ENOblock Does Not Inhibit the Activity of the Glycolytic Enzyme Enolase	PLoS ONE 11(12): e0168739. doi:10.1371	2016	UNITED STATES of AMERICA	Click for Article
Cancer	Sandt et al.	Use of infrared microspectroscopy to elucidate a specific chemical signature associated with hypoxia levels found in glioblastoma	Analyst. 2016 Feb 7;141(3):870-83 2016	2016	FRANCE	Click for Article
Cancer	Rouschop et al.	PERK/eIF2 α signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS	PNAS March 19, 2013 vol. 110 no. 12	2013	NETHERLANDS	Click for Article
Cancer	Rodríguez-Bárzano et al.	Synthesis and anticancer activity evaluation of η5-C5(CH3)4R ruthenium complexes bearing chelating diphosphine ligands	Dalton Trans., 2015,44, 3265-3270	2015	UNITED KINGDOM	Click for Article
Cancer	Rodenhizer et al.	A three-dimensional engineered tumour for spatial snapshot analysis of cell metabolism and phenotype in hypoxic gradients	Nature Materials 15, 227–234 2016	2016	CANADA	Click for Article
Cancer	Richards et al.	Cell cycle progression in glioblastoma cells is unaffected by pathophysiological levels of hypoxia	PeerJ 4:e1755 2016	2016	UNITED KINGDOM	Click for Article
Cancer	Rey et al.	Molecular targeting of hypoxia in radiotherapy	Advanced Drug Delivery Reviews 2016	2016	CANADA	Click for Article
Cancer	Quero et al.	miR-210 as a marker of chronic hypoxia, but not a therapeutic target in prostate cancer	Radiotherapy and Oncology 101 (2011) 203–208	2011	FRANCE	Click for Article
Cancer	Prickaerts et al.	Hypoxia increases genome‑wide bivalent epigenetic marking by specific gain of H3K27me3	Epigenetics & Chromatin (2016) 9:46	2016	CANADA	Click for Article
Cancer	Pietras et al.	JAG2 Induction in Hypoxic Tumor Cells Alters Notch Signaling and Enhances Endothelial Cell Tube Formation	Mol Cancer Res; 9(5) May 2011	2011	SWEDEN	Click for Article
Cancer	Persson et al.	HIF-2 Expression Is Suppressed in SCLC Cells, Which Survive in Moderate and Severe Hypoxia When HIF-1 Is Repressed	The American Journal of Pathology, Vol. 180, No. 2, February 2012	2012	SWEDEN	Click for Article
Cancer	Palazon et al.	The HIF-1 Hypoxia Response in Tumor-Infiltrating T Lymphocytes Induces Functional CD137 (4-1BB)	Cancer Discov; 2(7); 608–23 2012	2012	SPAIN	Click for Article
Cancer	Pahlman et al.	Differential HIF-1α and HIF-2α Expression in Mammary Epithelial Cells during Fat Pad Invasion, Lactation, and Involution	PLOS ONE \| DOI:10.1371 2015	2015	FINLAND	Click for Article
Cancer	Nagelkerke et al.	Hypoxic Regulation and Prognostic Value of LAMP3 Expression in Breast Cancer	Cancer, Volume 117, Issue 16 15 August 2011 Pages 3670–3681	2011	NETHERLANDS	Click for Article
Cancer	Nagelkerke et al.	Hypoxia stimulates migration of breast cancer cells via the PERK/ATF4/LAMP3-arm of the unfolded protein response	BreastCancerResearch 2013, 15 :R2	2013	NETHERLANDS	Click for Article
Cancer	Mysore et al.	A DNA binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma has Potent Anti tumor Activity	Mol Cancer Res March 2016 14:253-266	2016	UNITED STATES of AMERICA	Click for Article
Cancer	Munksgaard-Persson	HIF-2 Expression Is Suppressed in SCLC Cells, Which Survive in Moderate and Severe Hypoxia When HIF-1 Is Repressed	The American Journal of Pathology, Vol. 180, No. 2, February 2012	2012	SWEDEN	Click for Article
Cancer	Mujcic	Hypoxic Activation of the PERK/eIF2 α Arm of the Unfolded Protein Response Promotes Metastasis through Induction of LAMP3	Clin Cancer Research 2013;19:6126-6137.	2013	CANADA	Click for Article
Cancer	Mudie et al.	TX1, a specificity determinant in the HIF-1 α -mediated transcriptional response to hypoxia	Cell Cycle 13:24, 3878--3891; 2014	2014	UNITED KINGDOM	Click for Article
Cancer	Mohlin et al.	HIF2A and IGF2 Expression Correlates in Human Neuroblastoma Cells and Normal Immature Sympathetic Neuroblasts	Neoplasia 2013 Vol. 15, No. 3, 328-34	2013	SWEDEN	Click for Article
Cancer	Mohlin et al.	PI3K-mTORC2 but not PI3K-mTORC1 regulates transcription of HIF2A/EPAS1 and vascularization in neuroblastoma	Cancer Res 2015; 75(21); 4617–28	2015	SWEDEN	Click for Article
Cancer	Martinez-Poveda	Non-invasive monitoring of hypoxia-inducible factor activation by optical imaging during antiangiogenic treatment in a xenograft model of ovarian carcinoma	INTERNATIONAL JOURNAL OF ONCOLOGY 39: 543-552, 2011	2011	SPAIN	Click for Article
Cancer	Maeda et al.	In Vivo Imaging Reveals Significant Tumor Vascular Dysfunction and Increased Tumor Hypoxia-Inducible Factor-1α Expression Induced by High Single-Dose Irradiation in a Pancreatic Tumor Model.	Int J Radiat Oncol Biol Phys. 2016 Sep 14. pii: S0360-3016(16)33174-	2016	UNITED STATES of AMERICA	Click for Article
Cancer	Maeda et al.	In Vivo Imaging Reveals Significant Tumor Vascular Dysfunction and Increased Tumor Hypoxia-Inducible Factor-1α Expression Induced by High Single-Dose Irradiation in a Pancreatic Tumor Model.	Int J Radiat Oncol Biol Phys. 2016 Sep 14. pii: S0360-3016(16)33174-	2016	CANADA	Click for Article
Cancer	Madsen et al.	Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis	EMBO Reports (2015) 16:1394–1408	2015	DENMARK	Click for Article
Cancer	Leszczynska et al.	Mechanisms and consequences of ATMIN repression in hypoxic conditions: roles for p53 and HIF-1	Scientific Reports 6:21698 2016	2016	UNITED KINGDOM	Click for Article
Cancer	LaChance et al.	DNMT3a epigenetic program regulates the HIF-2α oxygen-sensing pathway and the cellular response to hypoxia	Proc Natl Acad Sci U S A. 2014 May 27; 111(21): 7783–7788	2014	CANADA	Click for Article
Cancer	Labiano et al.	Hypoxia-induced soluble CD137 in malignant cells blocks CD137L-costimulation as an immune escape mechanism	OncoImmunology Volume 5, Issue 1, 2016	2016	SPAIN	Click for Article
Cancer	Knoll et al.	Hypoxia regulates TRAIL sensitivity of colorectal cancer cells through mitochondrial autophagy	Oncotarget. 2016 Jul 5;7(27):41488-41504	2016	GERMANY	Click for Article
Cancer	Jiang et al.	Hypoxia Potentiates the Radiation-Sensitizing Effect of Olaparib in Human Non-Small Cell Lung Cancer Xenografts by Contextual Synthetic Lethality	Int J Radiation Oncol Biol Phys, Vol. 95, No. 2, pp. 772 e781, 2016	2016	UNITED KINGDOM	Click for Article
Cancer	Hunter et al.	Hypoxia-activated prodrugs: paths forward in the era of personalised medicine	Br J Cancer. 2016 May 10; 114(10): 1071–1077.	2016	UNITED STATES of AMERICA & NEW ZEALAND	Click for Article
Cancer	Humtsoe et al.	ErbB3 upregulation by the HNSCC 3D microenvironment modulates cell survival and growth	Oncogene 35, 1554-1564 (24 March 2016)	2016	UNITED STATES of AMERICA	Click for Article
Cancer	Hevia et al.	Human colon-derived soluble factors modulate gut microbiota composition	Front. Oncol. 5:86. 2015	2015	SPAIN	Click for Article
Cancer	Herzog et al.	Cyclin-dependent kinase 5 stabilizes hypoxia-inducible factor-1α: a novel approach for inhibiting angiogenesis in hepatocellular carcinoma	Oncotarget. 2016 May 10; 7(19): 27108–27121	2016	GERMANY	Click for Article
Cancer	Herrmann et al.	Cellular memory of hypoxia elicits neuroblastoma metastasis and enables invasion by non-aggressive neighbouring cells.	Oncogenesis. 2015 Feb; 4(2): e138.	2015	UNITED KINGDOM	Click for Article
Cancer	Hansson et al.	Overexpression of functional SLC6A3 in clear cell renal cell carcinoma	Clin Cancer Res. 2016 Sep 23	2016	SWEDEN	Click for Article
Cancer	Hamidian et al.	Differential regulation of HIF-1a and HIF-2a in neuroblastoma: Estrogen-related receptor alpha (ERRa) regulates HIF2A transcription and correlates to poor outcome	Biochemical and Biophysical Research Communications 461 (2015) 560 -567	2015	SWEDEN	Click for Article
Cancer	Hai et al.	TRIM14 is a Putative Tumor Suppressor and Regulator of Innate Immune Response in Non-Small Cell Lung Cancer	Scientific Reports 7, Article number: 39692 (2017)	2017	CANADA	Click for Article
Cancer	Gomez-Maldonado et al.	EFNA3 long noncoding RNAs induced by hypoxia promote metastatic dissemination	Oncogene (2014), 1–12	2014	SPAIN	Click for Article
Cancer	Flett et al.	Gulonolactone Addition to Human Hepatocellular Carcinoma Cells with Gene Transfer of Gulonolactone Oxidase Restores Ascorbate Biosynthesis and Reduces Hypoxia Inducible Factor 1	Biomedicines 2014, 2(1), 98-109	2014	NEW ZEALAND	Click for Article
Cancer	Fitzgerald et al.	Nox4 Mediates Renal Cell Carcinoma Cell Invasion through Hypoxia-Induced Interleukin 6- and 8- Production	PLoS One. 2012; 7(1): e30712	2012	UNITED STATES of AMERICA	Click for Article
Cancer	Fernandez-Barral	Hypoxia Negatively Regulates Antimetastatic PEDF in Melanoma Cells by a Hypoxia Inducible Factor-Independent, Autophagy Dependent Mechanism.	PLoS ONE 2012; 7(3): e32989.	2012	SPAIN	Click for Article
Cancer	Elkashef et al.	Polysialic acid sustains cancer cell survival and migratory capacity in a hypoxic environment	Nature Scientific Reports 2016 6:33026	2016	UNITED KINGDOM	Click for Article
Cancer	Eales et al.	Hypoxia and metabolic adaptation of cancer cells	Oncogenesis (2016) 5	2016	UNITED KINGDOM	Click for Article
Cancer	Doherty et al.	Photodynamic killing of cancer cells by a Platinum(II) complex with cyclometallating ligand	Nature Scientific Reports 6:22668 2016	2016	UNITED KINGDOM	Click for Article
Cancer	Djidja et al.	Identification of Hypoxia-Regulated Proteins Using MALDI-Mass Spectrometry Imaging Combined with Quantitative Proteomics	J. Proteome Res., 2014, 13 (5), pp 2297–2313	2014	UNITED KINGDOM	Click for Article
Cancer	Dixon et al.	Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis	eLife 2014;3:e02523	2014	UNITED STATES of AMERICA	Click for Article
Cancer	del Poggetto et al.	Salarin C inhibits the maintenance of chronic myeloid leukemia progenitor cells	Cell Cycle, Vol. 14, Iss. 19, 2015	2015	ITALY	Click for Article
Cancer	Cronin et al.	High Resolution In Vivo Bioluminescent Imaging for the Study of Bacterial Tumour Targeting	PLoS ONE 7(1): e30940 2012	2012	IRELAND	Click for Article
Cancer	Cox et al.	The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase	Nature 522, 106–110 2015	2015	UNITED KINGDOM	Click for Article
Cancer	Cox et al.	Dataset for the proteomic inventory and quantitative analysis of the breast cancer hypoxic secretome associated with osteotropism	Data in Brief 5 (2015) 621-625	2015	UNITED KINGDOM	Click for Article
Cancer	Collet et al.	Endothelial precursor cell-based therapy to target the pathologic angiogenesis and compensate tumor hypoxia	Cancer Letters 370 (2016) 345–357	2016	POLAND	Click for Article
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