Hypoxia and the Hallmarks of Cancer
from HypOxygen

HallmarksHypoxiaWeb

The Hallmarks of Cancer are directly affected, and in many cases even caused, by hypoxia as a defining feature of tumors. Oxygen in the tumor microenvironment and within the cells is central to metabolism, immunology, epigenetics and therapy resistance of all the cancers. The recent review by HypOxystation users Wigerup and Pahlman illustrates how "tumor hypoxia affects most of the Cancer Hallmarks".* Cell culture at very low oxygen in the HypOxystation mimics the in vivo conditions encountered by cancer cells. The HypOxystation hypoxia workstation enables glove-less access to cultivate and manipulate cells under physio- logical conditions, in a HEPA- clean environment.

* "Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer" Pharmacology & Therapeutics 164 (2016)


Why Choose the HypOxystation for Cancer Research Applications

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Choose Your Cell Culture Environment

Specifically designed to create normoxic, hypoxic and anoxic conditions within a controlled and sustained workstation environment. This hypoxic incubator is ideal for research requiring the ability to accurately control O2, CO2, temperature and humidity. Application possibilities for HypOxystation are endless; it is being used for research into tumor microenvironment, hypoxia pathways and HIF signaling, in vitro modeling of in situ environments, cancer cell metastasis, angiogenesis, and many other fields where cells may benefit from a physiological atmosphere.

H45Features

- Control O2 in 0.1% increments from 0.1% - 20%

- Control CO2 in 0.1% increments from 0.1% - 15%

- Control relative humidity up to 90%

- Control temperature easily and precisely

- Touch screen interface to monitor all parameters simultaneously

- Straightforward calibration of gas sensors without removing sensors from the chamber or disrupting the working atmosphere

- Real time feedback system monitors and adjusts O2 levels to insure accuracy; CO2 feedback is also available

- Eight size models to choose from to meet your research needs

Click here for more information on the HypOxystation 

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What Our Users Are Saying


HypOxygen Supports Research

Researcher Travel Grants

Our annual research travel grants are allocated for HypOxystation users and allows receipients to attend conferences, take colleagues, attend meetings and tradeshows, be a keynote speaker, the possibilities are endless!  Here are our past recipients:

2020

Serina Cheung is currently a second year MSc student in Dr. Marianne Koritzinsky’s lab. She is investigating the role of p38 mitogen-activation protein kinase in promoting the survival of castration-resistant prostate cancer under hypoxia. 

Ronald Wu is a PhD candidate in Dr. Brad Wouters lab at the University of Toronto and is investigating the role of hypoxia on oxygen-dependent DNA and histone demethylases in glioblastoma. Specifically, he is interested in the epigenetic mechanisms governing self-renewal and differentiation in this deadly brain tumour. 

Sandy Lee is a third year PhD student in Dr. Marianne Koritzinsky’s lab within the Institute of Medical Science at the University of Toronto. She is investigating how different levels of oxygen can mediate the folding process of a protein. She is interested in proteins that cause aggressive cancer phenotypes.

Stephanie Hulme is currently a second year MSc student in Dr. Marianne Koritzinsky’s lab. She is investigating protein secretion rates of VEGF and CA9 under normoxic and anoxic oxygen conditions.

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2019

Dan Cojocari and Elizabeth Koch of the Princess Margaret Cancer Centre in Toronto, Canada. The authors, who grow their cell cultures at very low oxygen in the HypOxystation, presented their findings, "Autophagy Promotes Tolerance to Hypoxia through Maintenance of Metabolic Homeostasis" at the 14th International Wolfsberg Meeting on Molecular Radiation Biology & Oncology in Switzerland.

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CellPress Cancer Research Week

CellpressScreen

HypOxygen and Don Whitley Scientific are proud to support CellPress in their efforts to provide research information and relevant panel discussions in lieu of conferences and tradeshows for 2020. 

The Cancer Research Hub can be accessed here 

 

Hypoxia in Cancer websiteCellPress Selections: Hypoxia in Cancer

HypOxygen and Don Whitley Scientific have teamed up with Cell Press to provide you with the latest research articles involving hypoxia and cancer. The articles compiled in this reprint collection showcase current progress in hypoxia in cancer—from an intravital imaging approach to monitor hypoxic regions in pancreatic cancer to a proposed combination therapy using an antiangiogenic drug to induce hypoxia with a drug targeting lipid metabolism. You can download them here for FREE!

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Publications

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Research FieldAuthorsTitle of PaperCitation/JournalPublication DateCountry
of Origin
Link to Publication
Cancer Niu et al. BRD7 inhibits the Warburg effect and tumor progression through inactivation of HIF1α/LDHA axis in breast cancer Cell Death Dis. 2018 May; 9(5): 519. 2018 CHINA Click for
Article
Cancer Chhipa et al. AMP Kinase Promotes Glioblastoma Bioenergetics and Tumor Growth Nat Cell Biol. Author manuscript; available in PMC 2018 Dec 18. 2018 UNITED STATES of AMERICA Click for
Article
Cancer Hermann et al. Magnetic Resonance Imaging for Characterization of a Chick Embryo Model of Cancer Cell Metastases Mol Imaging. 2018 Jan-Dec; 17: 1536012118809585. 2018 UNITED KINGDOM Click for
Article
Cancer Wohlrab et al. The Association Between Ascorbate and the Hypoxia-Inducible Factors in Human Renal Cell Carcinoma Requires a Functional Von Hippel-Lindau Protein Front Oncol. 2018; 8: 574. 2018 NEW ZEALAND Click for
Article
Cancer Cao et al. miR-18a reactivates the Epstein-Barr virus through defective DNA damage response and promotes genomic instability in EBV-associated lymphomas BMC Cancer. 2018; 18: 1293. 2018 CHINA Click for
Article
Cancer Jamieson et al. Evofosfamide for the treatment of human papillomavirus-negative head and neck squamous cell carcinoma JCI Insight. 2018 Aug 23; 3(16): e122204. 2018 NEW ZEALAND Click for
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Cancer Al-Mutawa et al. Effects of hypoxic preconditioning on neuroblastoma tumour oxygenation and metabolic signature in a chick embryo model Biosci Rep. 2018 Aug 31; 38(4): BSR20180185. 2018 UNITED KINGDOM Click for
Article
Cancer Eales et al. Verteporfin selectively kills hypoxic glioma cells through iron-binding and increased production of reactive oxygen species Sci Rep. 2018; 8: 14358. 2018 UNITED KINGDOM Click for
Article
Cancer Ho et al. Systemic reprograming of translation efficiencies on oxygen stimulus Cell Rep. Author manuscript; available in PMC 2016 Mar 9. 2016 UNITED STATES of AMERICA Click for
Article
Cancer Gammoh et al. Suppression of autophagy impedes glioblastoma development and induces senescence Autophagy. 2016; 12(9): 1431–1439. 2016 UNITED KINGDOM Click for
Article
Cancer Leszczynska, et al. Preclinical testing of an Atr inhibitor demonstrates improved response to standard therapies for esophageal cancer Radiother Oncol. 2016 Nov; 121(2): 232–238. 2016 UNITED KINGDOM Click for
Article
Cancer O'Connor et al. CYP450 Enzymes Effect Oxygen-Dependent Reduction of Azide-Based Fluorogenic Dyes ACS Cent Sci. 2017 Jan 25; 3(1): 20–30. 2017 UNITED KINGDOM Click for
Article
Cancer Labiano et al. CD69 is a direct HIF-1α target gene in hypoxia as a mechanism enhancing expression on tumor-infiltrating T lymphocytes Oncoimmunology. 2017; 6(4): e1283468. 2017 SPAIN Click for
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Cancer Wadkin et al. CD151 supports VCAM-1-mediated lymphocyte adhesion to liver endothelium and is upregulated in chronic liver disease and hepatocellular carcinoma Am J Physiol Gastrointest Liver Physiol. 2017 Aug 1; 313(2): G138–G149. 2017 UNITED KINGDOM Click for
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Cancer Poupard et al. Assessment of Heparanase-Mediated Angiogenesis Using Microvascular Endothelial Cells: Identification of λ-Carrageenan Derivative as a Potent Anti Angiogenic Agent Mar Drugs. 2017 May; 15(5): 134. 2017 FRANCE Click for
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Cancer Dobrynin et al. KDM4A regulates HIF-1 levels through H3K9me3 Sci Rep. 2017; 7: 11094. 2017 UNITED KINGDOM Click for
Article
Cancer Kelly et al. Hypoxia activates cadherin-22 synthesis via eIF4E2 to drive cancer cell migration, invasion and adhesion Oncogene. Author manuscript; available in PMC 2018 Feb 6. 2018 CANADA Click for
Article
Cancer Krawczyk et al. Injury induced expression of caveolar proteins in human kidney tubules - role of megakaryoblastic leukemia 1 BMC Nephrol. 2017; 18: 320. 2017 SWEDEN Click for
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Cancer Paredes et al. Poldip2 is an oxygen-sensitive protein that controls PDH and αKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer Proc Natl Acad Sci U S A. 2018 Feb 20; 115(8): 1789–1794. 2018 UNITED STATES of AMERICA Click for
Article
Cancer Chandrashekhar et al. Transducer like proteins of Campylobacter jejuni 81-176: role in chemotaxis and colonization of the chicken gastrointestinal tract Front Cell Infect Microbiol. 2015; 5: 46. 2015 UNITED STATES of AMERICA Click for
Article
Cancer Stivarou et al. The complex metabolic network gearing the G1/S transition in leukemic stem cells: Hints to a rational use of antineoplastic agents Oncotarget. 2015 Oct 13; 6(31): 31985–31996. 2015 ITALY Click for
Article
Cancer Yu et al. Berberine may rescue Fusobacterium nucleatum-induced colorectal tumorigenesis by modulating the tumor microenvironment Oncotarget. 2015 Oct 13; 6(31): 32013–32026. 2015 CHINA Click for
Article
Cancer Cheloni et al. The Leukemic Stem Cell Niche: Adaptation to “Hypoxia” versus Oncogene Addiction Stem Cells Int. 2017; 2017: 4979474. 2017 ITALY Click for
Article
Cancer Yu et al. Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy Cell. Author manuscript; available in PMC 2018 Jan 13. 2017 CHINA Click for
Article
Cancer Sordi et al. Development of Photodynamic Antimicrobial Chemotherapy (PACT) for Clostridium difficile PLoS One. 2015; 10(8): e0135039. 2015 UNITED KINGDOM Click for
Article
Cancer Rodenhizer et al. A 3D engineered tumour for spatial snap-shot analysis of cell metabolism and phenotype in hypoxic gradients Nat Mater. 2016 Feb; 15(2): 227–234. 2016 UNITED KINGDOM Click for
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Cancer Olivares et al. Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions Nat Commun. 2017; 8: 16031. 2017 FRANCE Click for
Article
Cancer Almodares et al. Rhodium, Iridium, and Ruthenium Half-Sandwich Picolinamide Complexes as Anticancer Agents Inorg. Chem., 2014, 53 (2), pp 727–736 2014 UNITED KINGDOM Click for
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Cancer Padro et al. Genome-independent hypoxic repression of estrogen receptor alpha in breast cancer cells BMC Cancer (2017) 17:203 2017 UNITED STATES of AMERICA Click for
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Cancer Meehan et al. Inhibition of pH regulation as a therapeutic strategy in hypoxic human breast cancer cells Oncotarget. 2017 Jun 27;8(26):42857-42875 2017 UNITED KINGDOM Click for
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Cancer Bulusu et al. Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation Cell Reports 18, 647–658 (2017) 2017 UNITED KINGDOM Click for
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Cancer Kalenderoglou et al. Cannabidiol Reduces Leukemic Cell Size – But Is It Important? Front. Pharmacol. 8:144 (2017) 2017 UNITED KINGDOM Click for
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Cancer Lord et al. Hypoxia Sensitive Metal #-Ketoiminate Complexes Showing Induced Single Strand DNA Breaks and Cancer Cell Death by Apoptosis J. Med. Chem., 2015, 58 (12), pp 4940–4953 2015 UNITED KINGDOM Click for
Article
Cancer O'Connor et al. Design, synthesis and evaluation of molecularly targeted hypoxia-activated prodrugs Nature Protocols 11, 781–794 (2016) 2016 UNITED KINGDOM Click for
Article
Cancer Horemans et al. In-vivo evaluation of apocynin for prevention of Helicobacter pylori-induced gastric carcinogenesis Eur J Cancer Prev. 2017 Jan;26(1):10-16. 2017 BELGIUM Click for
Article
Cancer Thoren et al. Myc-induced glutaminolysis bypasses HIF-driven glycolysis in hypoxic small cell lung carcinoma cells Oncotarget, 2017, Vol. 8, (No. 30), pp: 48983-48995 2017 SWEDEN Click for
Article
Cancer Chen et al. Autophagy enhanced the radioresistance of nonsmall cell lung cancer by regulating ROS level under hypoxia condition International Journal of Radiation Biology, 2017 DOI: 10.1080/09553002.2017.1325025 2017 CHINA Click for
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Cancer Cheloni et al. Targeting chronic myeloid leukemia stem cells with the hypoxia-inducible factor inhibitor acriflavine Blood 2017 :blood-2016-10-745588 2016 ITALY Click for
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Cancer Xintaropoulou et al. A comparative analysis of inhibitors of the glycolysis pathway in breast and ovarian cancer cell line models Oncotarget, Vol. 6, No. 28 2015 2015 UNITED KINGDOM Click for
Article
Cancer Wilson et al. Hypoxia inducible factors in liver disease and hepatocellular carcinoma: Current understanding and future directions Journal of Hepatology 2014 vol. 61, 1397–1406 2014 UNITED KINGDOM Click for
Article
Cancer Wigerup et al. Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer Pharmacology & Therapeutics; Vol. 164, August 2016, Pages 152–169 2016 SWEDEN Click for
Article
Cancer Wennemers et al. Regulation of TRIB3 mRNA and Protein in Breast Cancer PLoS ONE 7(11):e49439 2012 2012 NETHERLANDS Click for
Article
Cancer Wennemers et al. Tribbles homolog 3 denotes a poor prognosis in breast cancer and is involved in hypoxia response BreastCancerResearch 2011, 13:R82 2011 NETHERLANDS Click for
Article
Cancer Weiss et al. Palladium-Mediated Dealkylation of N-Propargyl-Floxuridine as a Bioorthogonal Oxygen-Independent Prodrug Strategy SCIENTIFIC REPORTS 5 : 9329 2015 2015 UNITED KINGDOM Click for
Article
Cancer Ward et al. Evaluation of carbonic anhydrase IX as a therapeutic target for inhibition of breast cancer invasion and metastasis using a series of in vitro breast cancer models Oncotarget. 2015;6(28):24856-24870. 2015 UNITED KINGDOM Click for
Article
Cancer van den Beucken et al. Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of ​DICER Nature Communications 5, Article number: 5203 2014 2014 UNITED STATES of AMERICA Click for
Article
Cancer van de Schootbrugge et al. αB-crystallin stimulates VEGF secretion and tumor cell migration and correlates with enhanced distant metastasis in head and neck squamous cell carcinoma MCCancer 2013, 13:128 2013 NETHERLANDS Click for
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Cancer van de Schootbrugge et al. Effect of hypoxia on the expression of αB-crystallin in head and neck squamous cell carcinoma BMC Cancer(2014)14:252 2014 NETHERLANDS Click for
Article
Cancer Vaapil et al. Hypoxic Conditions Induce a Cancer-Like Phenotype in Human Breast Epithelial Cells PLoS ONE 7(9): e46543. doi:10.1371 (2012) 2012 SWEDEN Click for
Article
Cancer Uniacke et al. Cancer cells exploit eIF4E2-directed synthesis of hypoxia response proteins to drive tumor progression Cancer Res. 2014 Mar 1;74(5):1379-89 2014 CANADA Click for
Article
Cancer Tan et al. Role of Autophagy as a Survival Mechanism for Hypoxic Cells in Tumors Neoplasia (2016) 18, 347–355 2016 CANADA Click for
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Cancer Sun et al. Hypoxic Regulation of Glutamine Metabolism through HIF1 and SIAH2 Supports Lipid Synthesis that Is Necessary for Tumor Growth Cell Metab. 2014 February 4; 19(2): 285–292 2014 UNITED STATES of AMERICA Click for
Article
Cancer Stegeman et al. Activation of AKT by hypoxia: a potential target for hypoxic tumors of the head and neck BMCCancer 2012, 12:463 2012 NETHERLANDS Click for
Article
Cancer Stegeman et al. Interaction between hypoxia, AKT and HIF-1 signaling in HNSCC and NSCLC: implications for future treatment strategies Future Sci. OA (2016) 2(1), FSO84 2016 2016 NETHERLANDS Click for
Article
Cancer Starmans et al. The prognostic value of temporal in vitro and in vivo derived hypoxia gene-expression signatures in breast cancer Radiotherapy and Oncology 102 (2012) 436–443 2012 NETHERLANDS Click for
Article
Cancer Sonke et al. Inhibition of endogenous hydrogen sulfide production in clear-cell renal cell carcinoma cell lines and xenografts restricts their growth, survival and angiogenic potential Nitric Oxide 49 (2015) 26-39 2015 CANADA Click for
Article
Cancer Škrtić et al. INHIBITION OF MITOCHONDRIAL TRANSLATION AS A THERAPEUTIC STRATEGY FOR HUMAN ACUTE MYELOID LEUKEMIA Cancer cell. 2011;20(5):674-688. 2011 CANADA Click for
Article
Cancer Schaaf et al. The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia Radiotherapy and Oncology 108 (2013) 529–534 2013 NETHERLANDS Click for
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Cancer Satani et al. ENOblock Does Not Inhibit the Activity of the Glycolytic Enzyme Enolase PLoS ONE 11(12): e0168739. doi:10.1371 2016 UNITED STATES of AMERICA Click for
Article
Cancer Sandt et al. Use of infrared microspectroscopy to elucidate a specific chemical signature associated with hypoxia levels found in glioblastoma Analyst. 2016 Feb 7;141(3):870-83 2016 2016 FRANCE Click for
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Cancer Rouschop et al. PERK/eIF2 α signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS PNAS March 19, 2013 vol. 110 no. 12 2013 NETHERLANDS Click for
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Cancer Rodríguez-Bárzano et al. Synthesis and anticancer activity evaluation of η5-C5(CH3)4R ruthenium complexes bearing chelating diphosphine ligands Dalton Trans., 2015,44, 3265-3270 2015 UNITED KINGDOM Click for
Article
Cancer Rodenhizer et al. A three-dimensional engineered tumour for spatial snapshot analysis of cell metabolism and phenotype in hypoxic gradients Nature Materials 15, 227–234 2016 2016 CANADA Click for
Article
Cancer Richards et al. Cell cycle progression in glioblastoma cells is unaffected by pathophysiological levels of hypoxia PeerJ 4:e1755 2016 2016 UNITED KINGDOM Click for
Article
Cancer Rey et al. Molecular targeting of hypoxia in radiotherapy Advanced Drug Delivery Reviews 2016 2016 CANADA Click for
Article
Cancer Quero et al. miR-210 as a marker of chronic hypoxia, but not a therapeutic target in prostate cancer Radiotherapy and Oncology 101 (2011) 203–208 2011 FRANCE Click for
Article
Cancer Prickaerts et al. Hypoxia increases genome‑wide bivalent epigenetic marking by specific gain of H3K27me3 Epigenetics & Chromatin (2016) 9:46 2016 CANADA Click for
Article
Cancer Pietras et al. JAG2 Induction in Hypoxic Tumor Cells Alters Notch Signaling and Enhances Endothelial Cell Tube Formation Mol Cancer Res; 9(5) May 2011 2011 SWEDEN Click for
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Cancer Persson et al. HIF-2 Expression Is Suppressed in SCLC Cells, Which Survive in Moderate and Severe Hypoxia When HIF-1 Is Repressed The American Journal of Pathology, Vol. 180, No. 2, February 2012 2012 SWEDEN Click for
Article
Cancer Palazon et al. The HIF-1 Hypoxia Response in Tumor-Infiltrating T Lymphocytes Induces Functional CD137 (4-1BB) Cancer Discov; 2(7); 608–23 2012 2012 SPAIN Click for
Article
Cancer Pahlman et al. Differential HIF-1α and HIF-2α Expression in Mammary Epithelial Cells during Fat Pad Invasion, Lactation, and Involution PLOS ONE | DOI:10.1371 2015 2015 FINLAND Click for
Article
Cancer Nagelkerke et al. Hypoxic Regulation and Prognostic Value of LAMP3 Expression in Breast Cancer Cancer, Volume 117, Issue 16 15 August 2011 Pages 3670–3681 2011 NETHERLANDS Click for
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Cancer Nagelkerke et al. Hypoxia stimulates migration of breast cancer cells via the PERK/ATF4/LAMP3-arm of the unfolded protein response BreastCancerResearch 2013, 15 :R2 2013 NETHERLANDS Click for
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Cancer Mysore et al. A DNA binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma has Potent Anti tumor Activity Mol Cancer Res March 2016 14:253-266 2016 UNITED STATES of AMERICA Click for
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Cancer Munksgaard-Persson HIF-2 Expression Is Suppressed in SCLC Cells, Which Survive in Moderate and Severe Hypoxia When HIF-1 Is Repressed The American Journal of Pathology, Vol. 180, No. 2, February 2012 2012 SWEDEN Click for
Article
Cancer Mujcic Hypoxic Activation of the PERK/eIF2 α Arm of the Unfolded Protein Response Promotes Metastasis through Induction of LAMP3 Clin Cancer Research 2013;19:6126-6137. 2013 CANADA Click for
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Cancer Mudie et al. TX1, a specificity determinant in the HIF-1 α -mediated transcriptional response to hypoxia Cell Cycle 13:24, 3878--3891; 2014 2014 UNITED KINGDOM Click for
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Cancer Mohlin et al. HIF2A and IGF2 Expression Correlates in Human Neuroblastoma Cells and Normal Immature Sympathetic Neuroblasts Neoplasia 2013 Vol. 15, No. 3, 328-34 2013 SWEDEN Click for
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Cancer Mohlin et al. PI3K-mTORC2 but not PI3K-mTORC1 regulates transcription of HIF2A/EPAS1 and vascularization in neuroblastoma Cancer Res 2015; 75(21); 4617–28 2015 SWEDEN Click for
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Cancer Martinez-Poveda Non-invasive monitoring of hypoxia-inducible factor activation by optical imaging during antiangiogenic treatment in a xenograft model of ovarian carcinoma INTERNATIONAL JOURNAL OF ONCOLOGY 39: 543-552, 2011 2011 SPAIN Click for
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Cancer Maeda et al. In Vivo Imaging Reveals Significant Tumor Vascular Dysfunction and Increased Tumor Hypoxia-Inducible Factor-1α Expression Induced by High Single-Dose Irradiation in a Pancreatic Tumor Model. Int J Radiat Oncol Biol Phys. 2016 Sep 14. pii: S0360-3016(16)33174- 2016 UNITED STATES of AMERICA Click for
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Cancer Maeda et al. In Vivo Imaging Reveals Significant Tumor Vascular Dysfunction and Increased Tumor Hypoxia-Inducible Factor-1α Expression Induced by High Single-Dose Irradiation in a Pancreatic Tumor Model. Int J Radiat Oncol Biol Phys. 2016 Sep 14. pii: S0360-3016(16)33174- 2016 CANADA Click for
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Cancer Madsen et al. Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis EMBO Reports (2015) 16:1394–1408 2015 DENMARK Click for
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Cancer Leszczynska et al. Mechanisms and consequences of ATMIN repression in hypoxic conditions: roles for p53 and HIF-1 Scientific Reports 6:21698 2016 2016 UNITED KINGDOM Click for
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Cancer LaChance et al. DNMT3a epigenetic program regulates the HIF-2α oxygen-sensing pathway and the cellular response to hypoxia Proc Natl Acad Sci U S A. 2014 May 27; 111(21): 7783–7788 2014 CANADA Click for
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Cancer Labiano et al. Hypoxia-induced soluble CD137 in malignant cells blocks CD137L-costimulation as an immune escape mechanism OncoImmunology Volume 5, Issue 1, 2016 2016 SPAIN Click for
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Cancer Knoll et al. Hypoxia regulates TRAIL sensitivity of colorectal cancer cells through mitochondrial autophagy Oncotarget. 2016 Jul 5;7(27):41488-41504 2016 GERMANY Click for
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Cancer Jiang et al. Hypoxia Potentiates the Radiation-Sensitizing Effect of Olaparib in Human Non-Small Cell Lung Cancer Xenografts by Contextual Synthetic Lethality Int J Radiation Oncol Biol Phys, Vol. 95, No. 2, pp. 772 e781, 2016 2016 UNITED KINGDOM Click for
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Cancer Hunter et al. Hypoxia-activated prodrugs: paths forward in the era of personalised medicine Br J Cancer. 2016 May 10; 114(10): 1071–1077. 2016 UNITED STATES of AMERICA & NEW ZEALAND Click for
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Cancer Humtsoe et al. ErbB3 upregulation by the HNSCC 3D microenvironment modulates cell survival and growth Oncogene 35, 1554-1564 (24 March 2016) 2016 UNITED STATES of AMERICA Click for
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Cancer Hevia et al. Human colon-derived soluble factors modulate gut microbiota composition Front. Oncol. 5:86. 2015 2015 SPAIN Click for
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Cancer Herzog et al. Cyclin-dependent kinase 5 stabilizes hypoxia-inducible factor-1α: a novel approach for inhibiting angiogenesis in hepatocellular carcinoma Oncotarget. 2016 May 10; 7(19): 27108–27121 2016 GERMANY Click for
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Cancer Herrmann et al. Cellular memory of hypoxia elicits neuroblastoma metastasis and enables invasion by non-aggressive neighbouring cells. Oncogenesis. 2015 Feb; 4(2): e138. 2015 UNITED KINGDOM Click for
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Cancer Hansson et al. Overexpression of functional SLC6A3 in clear cell renal cell carcinoma Clin Cancer Res. 2016 Sep 23 2016 SWEDEN Click for
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Cancer Hamidian et al. Differential regulation of HIF-1a and HIF-2a in neuroblastoma: Estrogen-related receptor alpha (ERRa) regulates HIF2A transcription and correlates to poor outcome Biochemical and Biophysical Research Communications 461 (2015) 560 -567 2015 SWEDEN Click for
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Cancer Hai et al. TRIM14 is a Putative Tumor Suppressor and Regulator of Innate Immune Response in Non-Small Cell Lung Cancer Scientific Reports 7, Article number: 39692 (2017) 2017 CANADA Click for
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Cancer Gomez-Maldonado et al. EFNA3 long noncoding RNAs induced by hypoxia promote metastatic dissemination Oncogene (2014), 1–12 2014 SPAIN Click for
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Cancer Flett et al. Gulonolactone Addition to Human Hepatocellular Carcinoma Cells with Gene Transfer of Gulonolactone Oxidase Restores Ascorbate Biosynthesis and Reduces Hypoxia Inducible Factor 1 Biomedicines 2014, 2(1), 98-109 2014 NEW ZEALAND Click for
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Cancer Fitzgerald et al. Nox4 Mediates Renal Cell Carcinoma Cell Invasion through Hypoxia-Induced Interleukin 6- and 8- Production PLoS One. 2012; 7(1): e30712 2012 UNITED STATES of AMERICA Click for
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Cancer Fernandez-Barral Hypoxia Negatively Regulates Antimetastatic PEDF in Melanoma Cells by a Hypoxia Inducible Factor-Independent, Autophagy Dependent Mechanism. PLoS ONE 2012; 7(3): e32989. 2012 SPAIN Click for
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Cancer Elkashef et al. Polysialic acid sustains cancer cell survival and migratory capacity in a hypoxic environment Nature Scientific Reports 2016 6:33026 2016 UNITED KINGDOM Click for
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Cancer Eales et al. Hypoxia and metabolic adaptation of cancer cells Oncogenesis (2016) 5 2016 UNITED KINGDOM Click for
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Cancer Doherty et al. Photodynamic killing of cancer cells by a Platinum(II) complex with cyclometallating ligand Nature Scientific Reports 6:22668 2016 2016 UNITED KINGDOM Click for
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Cancer Djidja et al. Identification of Hypoxia-Regulated Proteins Using MALDI-Mass Spectrometry Imaging Combined with Quantitative Proteomics J. Proteome Res., 2014, 13 (5), pp 2297–2313 2014 UNITED KINGDOM Click for
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Cancer Dixon et al. Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis eLife 2014;3:e02523 2014 UNITED STATES of AMERICA Click for
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Cancer del Poggetto et al. Salarin C inhibits the maintenance of chronic myeloid leukemia progenitor cells Cell Cycle, Vol. 14, Iss. 19, 2015 2015 ITALY Click for
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Cancer Cronin et al. High Resolution In Vivo Bioluminescent Imaging for the Study of Bacterial Tumour Targeting PLoS ONE 7(1): e30940 2012 2012 IRELAND Click for
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Cancer Cox et al. The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase Nature 522, 106–110 2015 2015 UNITED KINGDOM Click for
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Cancer Cox et al. Dataset for the proteomic inventory and quantitative analysis of the breast cancer hypoxic secretome associated with osteotropism Data in Brief 5 (2015) 621-625 2015 UNITED KINGDOM Click for
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Cancer Collet et al. Endothelial precursor cell-based therapy to target the pathologic angiogenesis and compensate tumor hypoxia Cancer Letters 370 (2016) 345–357 2016 POLAND Click for
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Cancer Campbell et al. Ascorbate availability affects tumor implantation-take rate and increases tumor rejection in Gulo–/– mice Hypoxia 2016:4 41–52 2016 NEW ZEALAND Click for
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Cancer Burrows et al. Hypoxia-induced nitric oxide production and tumour perfusion is inhibited by pegylated arginine deiminase (ADI-PEG20) Scientific Reports 6, Article number: 22950 2016 2016 UNITED KINGDOM Click for
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Cancer Banh et al. PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia Nature Cell Biology 18, 803–813 (2016) 2016 UNITED STATES of AMERICA Click for
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Cancer Baker et al. The HIF-pathway inhibitor NSC-134754 induces metabolic changes and anti-tumour activity while maintaining vascular function British Journal of Cancer (2012) 106, 1638–1647 2012 UNITED KINGDOM Click for
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Cancer Asby et al. Triggering apoptosis in cancer cells with an Org. Biomol. Chem., 2016 2016 UNITED KINGDOM Click for
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Cancer Alam et al. HIF2α contributes to antiestrogen resistance via positive bilateral Oncotarget 2016, Vol. 7, No. 10 2016 SWEDEN Click for
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Cancer Ahmadi et al. Hypoxia modulates the activity of a series of clinically approved tyrosine kinase inhibitors British Journal of Pharmacology. 2014;171(1):224-236 2014 UNITED KINGDOM Click for
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Cancer Adriaens et al. Quantitative analysis of ChIP‑seq data uncovers dynamic and sustained H3K4me3 and H3K27me3 modulation in cancer cells under hypoxia Epigenetics & Chromatin (2016) 9:48 2016 NETHERLANDS Click for
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