Hanahan and Weinberg’s seminal papers on the Hallmarks of Cancer describe how cancer cells accommodate the frenzied growth characteristic of tumors. Low oxygen is eminently characteristic of tumors, and in this hypoxic environment, metabolism is reprogrammed to satisfy energetic and synthetic needs of the cells.
Read more: Hypoxia and the Hallmarks of Cancer: Metabolic Reprogramming
By Angela Chen for the Verge.com
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Doctors created enough skin to cover 80 percent of the body of a seven-year-old boy with a genetic disease — and it saved his life.
This isn’t the first time that doctors have used genetic engineering to grow new skin, but past attempts only grew a little bit. This time, doctors were able to cover nine square feet of the patient’s body. The boy, who has a genetic skin disease called junctional epidermolysis bullosa (JEB), had been expected to die. Now, two years after the surgery, he lives a normal life and is able to play sports and exercise, the doctors say. The results were published today in the journal Nature.
Read more: Scientists save child’s life by growing him new skin
Based on the premise that the physiological range of oxygen in tissues is between 1- 8%, and pathologies from cancer to diabetes are characterized by much lower oxygen levels, researchers worldwide are cultivating their cell cultures in the HypOxystation by Don Whitley Scientific. The HypOxystation provides physiologically relevant conditions for cell culture and manipulation to ensure authentic behavior of cells. User-defined parameters for temperature, CO2, O2 and humidity, plus the workstation format, where cells reside throughout the entire duration of the assays, minimize the extra-physiologic oxygen shock that is known to negatively impact cell metabolism and growth.
Read more: Culturing Cells in Ambient Air, or Normoxia, is Far From Physiological
Cardiovascular disease, including heart disease and stroke, is responsible for approx. 1 in 3 deaths in the US, according to the American Heart Association. World Heart Day on September 29th serves as a platform to educate people on how to take control of their heart health.
Of all the “Hallmarks of Cancer” defined by Hanahan and Weinberg, the ability to proliferate indefinitely is often considered to be the most central to cancer’s core features. Sustaining Growth and Resisting Cell Death enable cancer cells to override signaling that ensures normal tissues’ homeostasis of numbers and size. Previous chapters in our mini-series on “Hypoxia and the Hallmarks of Cancer” have showcased Avoiding Immune Destruction and Tumor Promoting Inflammation and Genome Instability and Mutation and Enabling Replicative Immortality as well as Inducing Angiogenesis and Activating Invasion and Metastasis.
Read more: Hypoxia and the Hallmarks of Cancer: Sustaining Growth and Resisting Cell Death
Hanahan and Weinberg’s “Hallmarks of Cancer” are at the root of the multi-step progression of cancer, and they are all influenced by hypoxia in the tumor microenvironment. In this mini-review series, HypOxygen has been taking a closer look at the way HypOxystation users worldwide are delineating the effects of hypoxia on the Hallmarks of Cancer: so far, we’ve showcased Avoiding Immune Destruction and Tumor Promoting Inflammation and Genome Instability and Mutation and Enabling Replicative Immortality.
Read more: Hypoxia and the Hallmarks of Cancer: Angiogenesis and Metastasis
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